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Titolo:
No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism
Autore:
Willeit, M; Stastny, J; Pirker, W; Praschak-Rieder, N; Neumeister, A; Asenbaum, S; Tauscher, J; Fuchs, K; Sieghart, W; Hornik, K; Aschauer, HN; Brucke, T; Kasper, S;
Indirizzi:
Univ Vienna, Dept Gen Psychiat, Vienna, Austria Univ Vienna Vienna Austria v Vienna, Dept Gen Psychiat, Vienna, Austria Univ Vienna, Dept Clin Neurol, Vienna, Austria Univ Vienna Vienna Austria iv Vienna, Dept Clin Neurol, Vienna, Austria Univ Vienna, Div Biochem Psychiat, Vienna, Austria Univ Vienna Vienna Austria ienna, Div Biochem Psychiat, Vienna, Austria Wilhelminen Spital Stadt Wien, Dept Neurol, Vienna, Austria Wilhelminen Spital Stadt Wien Vienna Austria pt Neurol, Vienna, Austria Vienna Univ Technol, Inst Wahrscheinlichkeitstheorie & Stochast Prozes, Vienna, Austria Vienna Univ Technol Vienna Austria e & Stochast Prozes, Vienna, Austria
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 1, volume: 50, anno: 2001,
pagine: 8 - 12
SICI:
0006-3223(20010701)50:1<8:NEFIVR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; FUNCTIONAL POLYMORPHISM; DOPAMINE TRANSPORTERS; BINDING-KINETICS; MAJOR DEPRESSION; REGION; SPECT; BRAIN; DISORDER; SITES;
Keywords:
5-HTTLPR; beta-CIT; SPECT; serotonin transporter; serotonin transporter promoter gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Willeit, M Univ Vienna, Dept Gen Psychiat, Waehringer Gurtel 18-20, Vienna, Austria Univ Vienna Waehringer Gurtel 18-20 Vienna Austria a, Austria
Citazione:
M. Willeit et al., "No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism", BIOL PSYCHI, 50(1), 2001, pp. 8-12

Abstract

Background: A polymorphism in the serotonin transporter promoter gene region (5-HTTLPR) has been shown to influence the quantity of serotonin transporter expressed in human cell lines: the 5-HTTLPR short allele (s) has been associated with reduced 5-HTT expression when compared to cells carrying the 5-HTTLPR long allele (l). We performed a single photon emission computed tomography (SPECT) study using the ligand [I-123]-2-beta -carbomethoxy-3-beta-(4-iodophenyl)tropane ([I-123]-beta -CIT) to measure 5-HTT availability in 16 healthy subjects genotyped for 5-HTTLPR. Methods: SPECT scans were performed 24 hours after tracer injection, regions of interest anatomically corresponding to the thalamus-hypothalamus and mesencephalon-pons areas were compared to the binding in the cerebellum, representing the nondisplaceable [I-123]- beta -CIT-binding (results expressed as target activity minus cerebellum activity/cerebellum activity). DNA from peripheral nuclear blood cells was genotyped for 5-HTTLPR using standardpolymerase chain reaction methods. Results: Specific binding ratios in the thalamus-hypothalamus were 2.65 +/- 0.4 in subjects with the l/l genotype (n = 3), 2.76 +/- 0.5 in subjects with the l/s genotype (n = 9), and 2.77 +/- 0.4 in subjects with the s/s genotype (n = 4). Binding ratios in the mesencephalon-pons were 1.43 +/- 0.3 (l/l; n = 3), 1.37 +/- 0.3 (l/s; n = 9), and 1.28 +/- 0.3 (s/s; n = 4). Noneof these differences was statistically significant. Conclusions: Our data provide no evidence for in vivo functional regulation of 5-HTT availability by 5-HTTLPR in the thalamus-hypothalamus and mesencephalon-pons of healthy subjects. Biol Psychiatry 2001;50:8-12 (C) 2001 Society of Biological Psychiatry.

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Documento generato il 17/09/19 alle ore 23:26:33