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Titolo:
Effect of lithium on phosphoinositide metabolism in human brain: A proton decoupled P-31 magnetic resonance spectroscopy study
Autore:
Yildiz, A; Demopulos, CM; Moore, CM; Renshaw, PF; Sachs, GS;
Indirizzi:
Dokuz Eylul Univ, Sch Med, Dept Psychiat, Izmir, Turkey Dokuz Eylul Univ Izmir Turkey iv, Sch Med, Dept Psychiat, Izmir, Turkey Harvard Univ, Sch Med, Massachusetts Gen Hosp, Bipolar Program, Boston, MAUSA Harvard Univ Boston MA USA etts Gen Hosp, Bipolar Program, Boston, MAUSA Harvard Univ, McLean Hosp, Sch Med, Belmont, MA 02178 USA Harvard Univ Belmont MA USA 02178 an Hosp, Sch Med, Belmont, MA 02178 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 1, volume: 50, anno: 2001,
pagine: 3 - 7
SICI:
0006-3223(20010701)50:1<3:EOLOPM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOOD-STABILIZING AGENTS; SIGNAL-TRANSDUCTION PATHWAYS; MANIC-DEPRESSIVE ILLNESS; INOSITOL METABOLISM; INVIVO P-31; MYOINOSITOL; MODULATION; MECHANISM; SPECTRA; CNS;
Keywords:
lithium; inositol monophosphatase; proton decoupled P-31 MRS; inositol depletion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Yildiz, A 170 Sok Guller Apt 8-8, TR-35360 Izmir, Turkey 170 Sok Guller Apt 8-8 Izmir Turkey TR-35360 360 Izmir, Turkey
Citazione:
A. Yildiz et al., "Effect of lithium on phosphoinositide metabolism in human brain: A proton decoupled P-31 magnetic resonance spectroscopy study", BIOL PSYCHI, 50(1), 2001, pp. 3-7

Abstract

Background: The objective of our study was to evaluate whether lithium increases brain phosphomonoester (PME) levels in human subjects. Methods: Proton decoupled P-31 magnetic resonance spectra were obtained from eight healthy volunteers before and after the administration of lithium carbonate, 450 mg b.i.d, for 7 and 14 days. Results: Pairwise comparisons of the mole percent PME revealed a significant increase from baseline at day 7 and day 14 of lithium administration. Conclusions: An increase in PME concentration with 7 and 14 days of lithium administration in the human brain in vivo was observed. Because the inositol-1-monophosphate contributes to the PME peak, this result suggests that some of the initial actions of lithium may occur through a reduction of myo-inositol, which in turn may initiate a cascade of secondary changes at different levels of signal transduction process and gene expression in brain, effects that are ultimately responsible for the therapeutic benefits of lithium. Biol Psychiatry 2001;50: 3-7 (C) 2001 Society of Biological Psychiatry.

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Documento generato il 17/01/20 alle ore 20:43:04