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Titolo:
Array analysis of the genes regulated during neuronal differentiation of human embryonal cells
Autore:
Bani-Yaghoub, M; Felker, JM; Ozog, MA; Bechberger, JF; Naus, CCG;
Indirizzi:
Univ Western Ontario, Dept Anat & Cell Biol, London, ON N6A 5C1, Canada Univ Western Ontario London ON Canada N6A 5C1 London, ON N6A 5C1, Canada John P Robarts Res Inst, London, ON N6A 2K8, Canada John P Robarts Res Inst London ON Canada N6A 2K8 ndon, ON N6A 2K8, Canada
Titolo Testata:
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE
fascicolo: 4, volume: 79, anno: 2001,
pagine: 387 - 398
SICI:
0829-8211(200108)79:4<387:AAOTGR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; IN-VITRO; TERATOCARCINOMA CELL; ALZHEIMERS-DISEASE; SUBCELLULAR-LOCALIZATION; NERVOUS-SYSTEM; EPH RECEPTORS; NTERA-2 CELLS; RAT-BRAIN; RHO-GDI;
Keywords:
Atlas cDNA expression arrays; differentiation; neurodevelopment; neuron; NT2/D1 cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Naus, CCG Univ Western Ontario, Dept Anat & Cell Biol, London, ON N6A 5C1,Canada Univ Western Ontario London ON Canada N6A 5C1 N N6A 5C1, Canada
Citazione:
M. Bani-Yaghoub et al., "Array analysis of the genes regulated during neuronal differentiation of human embryonal cells", BIOC CELL B, 79(4), 2001, pp. 387-398

Abstract

Recent advances in genetic technology have provided a new platform on which the simultaneous analysis of a large number of genes is possible in a rapid and efficient fashion. To assess the differential expression of human genes during neuronal differentiation, we compared the transcript profiles ofundifferentiated, partially differentiated, and fully differentiated NT2/D1 cultures with cDNA expression arrays. Approximately 75 genes (13% of the gene array pool) were differentially expressed during neuronal development of NT2/D1 cells. Genes coding for pyruvate kinase M2 isozyme, clathrin assembly proteins, calmodulin, fibronectin, laminin, thymosin beta-10, and manyothers were upregulated as NT2/D1 cells differentiated into neurons. In contrast, several kinases, phosphatases, and G-protein coupled receptor genesshowed downregulation upon neuronal differentiation. The information provided here is an invaluable reference for characterizing the phenotype of these cells. This information can also be used in cell therapy and transplantation in which the graft microenvironment and interaction with the host tissue is crucial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:22:06