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Titolo:
Carnitine palmitoyl transferase I and the control of beta-oxidation in heart mitochondria
Autore:
Eaton, S; Bartlett, K; Quant, PA;
Indirizzi:
Inst Child Hlth, Unit Paediat Surg, London WC1N 1EH, England Inst Child Hlth London England WC1N 1EH t Surg, London WC1N 1EH, England Royal Victoria Infirm, Sir James Spence Inst Child Hlth, Dept Clin Biochem, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and Royal Victoria Infirm, Dept Child Hlth, Sir James Spence Inst Child Hlth, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 285, anno: 2001,
pagine: 537 - 539
SICI:
0006-291X(20010713)285:2<537:CPTIAT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID OXIDATION; FLUX CONTROL COEFFICIENTS; MALONYL-COA METABOLISM; PALMITOYLTRANSFERASE-I; RAT-HEART; CARDIAC MYOCYTES; SKELETAL-MUSCLE; ADULT-RATS; LIVER; KETOGENESIS;
Keywords:
heart; beta-oxidation; flux control coefficient; suckling; carnitine palmitoyl transferase I;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Eaton, S Inst Child Hlth, Unit Paediat Surg, 30 Guilford St, London WC1N 1EH, England Inst Child Hlth 30 Guilford St London England WC1N 1EH , England
Citazione:
S. Eaton et al., "Carnitine palmitoyl transferase I and the control of beta-oxidation in heart mitochondria", BIOC BIOP R, 285(2), 2001, pp. 537-539

Abstract

Mitochondrial beta -oxidation provides much of the fuel requirements of heart and skeletal muscle despite the malonyl-CoA concentration greatly exceeding the IC50 of carnitine palmitoyl transferase for malonyl-CoA. To try toexplore the relationship between inhibition of carnitine palmitoyl transferase I activity and beta -oxidation flux, we measured the flux control coefficient of carnitine palmitoyl transferase I over beta -oxidation carbon flux in suckling rat heart mitochondria. The flux control coefficient was found to be 0.08 +/- 0.05 and 50% of carnitine palmitoyl transferase I activity could be inhibited before beta -oxidation flux was affected. These observations may help to explain the presence of high rates of beta -oxidation despite the high concentration of malonyl-CoA in rat heart; we hypothesize that although not rate-limiting in vitro, carnitine palmitoyl transferase is rate-limiting in vivo because of the high malonyl-CoA concentration in heart and muscle. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:15:06