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Titolo:
New insights into the regulation of cathepsin K gene expression by osteoprotegerin ligand
Autore:
Corisdeo, S; Gyda, M; Zaidi, M; Moonga, BS; Troen, BR;
Indirizzi:
Vet Adm Med Ctr, GRECC 526, Bronx, NY 10468 USA Vet Adm Med Ctr Bronx NY USA 10468 ed Ctr, GRECC 526, Bronx, NY 10468 USA CUNY Mt Sinai Sch Med, Dept Geriatr & Adult Dev, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 t Dev, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 t Med, New York, NY 10029 USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 2, volume: 285, anno: 2001,
pagine: 335 - 339
SICI:
0006-291X(20010713)285:2<335:NIITRO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
OSTEOCLASTIC BONE-RESORPTION; OVARIECTOMIZED MICE; RETINOIC ACID; PYCNODYSOSTOSIS; LOCALIZATION; OSTEOPETROSIS; HL-60;
Keywords:
osteoclast; osteoprotegerin ligand; macrophage colony-stimulating factor; cathepsin K; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Troen, BR Vet Adm Med Ctr, GRECC 526, 130 W Kingsbridge Rd, Bronx, NY 10468 USA Vet Adm Med Ctr 130 W Kingsbridge Rd Bronx NY USA 10468 0468 USA
Citazione:
S. Corisdeo et al., "New insights into the regulation of cathepsin K gene expression by osteoprotegerin ligand", BIOC BIOP R, 285(2), 2001, pp. 335-339

Abstract

Cathepsin K plays a key role in bone resorption. We provide the first evidence that osteoprotegerin ligand (OPGL), a critical pro-resorptive cytokine, acutely stimulates the expression of cathepsin K in osteoclasts. We used in situ RT-PCR and real time quantitative RT-PCR to analyze cathepsin K gene expression. OPGL enhanced cathepsin K mRNA levels in mature osteoclasts isolated from rat neonatal long bones. OPGL together with macrophage colony-stimulating factor (M-CSF) also stimulated cathepsin K gene expression in monocytic cells and multinucleate osteoclasts in bone marrow cultures. Real time quantitative RT-FCR demonstrated high levels of cathepsin K mRNA in bone marrow cultures, paralleling the degree off osteoclastogenesis. We therefore suggest that OPGL enhances bone resorption, at least in part, by inducing cathepsin K gene expression. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 10:37:54