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Titolo:
Pancreatic islet transplantation in the treatment of diabetes mellitus
Autore:
Shapiro, AMJ; Ryan, EA; Lakey, JRT;
Indirizzi:
Univ Alberta, Fac Med, Dept Surg, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada Fac Med, Dept Surg, Edmonton, AB, Canada Univ Alberta, Fac Med, Dept Med, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada Fac Med, Dept Med, Edmonton, AB, Canada
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
fascicolo: 2, volume: 15, anno: 2001,
pagine: 241 - 264
SICI:
1521-690X(200106)15:2<241:PITITT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-ALLOGRAFT REJECTION; QUALITY-OF-LIFE; KIDNEY TRANSPLANTATION; ENDOGENOUS RETROVIRUS; BLADDER DRAINAGE; INSULIN SENSITIVITY; TOLERANCE INDUCTION; GLUCOSE-TOLERANCE; TACROLIMUS FK506; FOOT ULCERATION;
Keywords:
islet; pancreas; diabetes; complications; isolation; collagenase; immunosuppression;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Shapiro, AMJ Univ Alberta, Fac Med, Dept Surg, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada Surg, Edmonton, AB, Canada
Citazione:
A.M.J. Shapiro et al., "Pancreatic islet transplantation in the treatment of diabetes mellitus", BEST PRAC R, 15(2), 2001, pp. 241-264

Abstract

This chapter reviews current developments and future directions in clinical islet transplantation. With the recent introduction of glucocorticoid-free immunosuppressive therapies and improved methods for islet isolation, thesuccess of the procedure has increased substantially. Challenges ahead include progress with international multicentre trials, development of single donor protocols, progress in clinical tolerance based therapies to lower overall risk of immunosuppression, and ultimately finding an alternative source to provide effective therapy for more patients with diabetes. Recent advances in stem cell biology and xenotransplantation may soon provide this opportunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:06:00