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Titolo:
Isotopic evaluation and therapy in patients with malignant endocrine disease
Autore:
Lewington, VJ; Clarke, SEM;
Indirizzi:
Southampton Univ Hosp, NHS Trust, Dept Nucl Med, Southampton SO16 6YD, Hants, England Southampton Univ Hosp Southampton Hants England SO16 6YD , Hants, England Guys Hosp, Dept Nucl Med, London SE1 9RT, England Guys Hosp London England SE1 9RT Dept Nucl Med, London SE1 9RT, England
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
fascicolo: 2, volume: 15, anno: 2001,
pagine: 225 - 239
SICI:
1521-690X(200106)15:2<225:IEATIP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOSTATIN RECEPTOR SCINTIGRAPHY; DIFFERENTIATED THYROID-CARCINOMA; POSITRON-EMISSION-TOMOGRAPHY; WHOLE-BODY SCINTIGRAPHY; FOLLOW-UP; NEUROENDOCRINE TUMORS; OCTREOTIDE SCINTIGRAPHY; PARATHYROID ADENOMAS; THYROGLOBULIN LEVELS; DOSE I-131;
Keywords:
tumour; radionuclide imaging; radiopharmaceutical; targeted radiotherapy; somatostatin receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Lewington, VJ Southampton Univ Hosp, NHS Trust, Dept Nucl Med, Tremona Rd,Southampton SO16 6YD, Hants, England Southampton Univ Hosp Tremona Rd Southampton Hants England SO16 6YD
Citazione:
V.J. Lewington e S.E.M. Clarke, "Isotopic evaluation and therapy in patients with malignant endocrine disease", BEST PRAC R, 15(2), 2001, pp. 225-239

Abstract

The contribution of nuclear medicine to the diagnosis and treatment of endocrine malignancy is increasing. Advances in molecular biology offer new opportunities for tumour targeting via surface receptor recognition and tumour-specific metabolic markers. Imaging the biodistribution of these markers allows quantitative, in vivo characterization of tumour function. There is growing interest in the therapeutic potential of nuclear medicine targeting, substituting therapeutic beta-emitting radionuclides for the gamma-emitters used in diagnostic imaging. Limited clinical experience supports the rationale of this approach in patients with inoperable or disseminated diseaseand controlled trials are in progress. This chapter outlines the place of nuclear medicine techniques in the routine management of endocrine malignancy and explores areas for further development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:21:08