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Titolo:
Effects of gonadal hormones and persistent pain on non-spatial working memory in male and female rats
Autore:
Ceccarelli, I; Scaramuzzino, A; Aloisi, AM;
Indirizzi:
Univ Siena, Inst Human Physiol, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 Inst Human Physiol, I-53100 Siena, Italy
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 123, anno: 2001,
pagine: 65 - 76
SICI:
0166-4328(20010827)123:1<65:EOGHAP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENDRITIC SPINE DENSITY; C-FOS EXPRESSION; SEX-DIFFERENCES; OBJECT RECOGNITION; MAZE PERFORMANCE; MEDIAL SEPTUM; ESTROUS-CYCLE; AGED RATS; HIPPOCAMPUS; ESTRADIOL;
Keywords:
object recognition test; sex differences; gonadectomy; formalin test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Aloisi, AM Univ Siena, Inst Human Physiol, Via Aldo Moro, I-53100 Siena, Italy Univ Siena Via Aldo Moro Siena Italy I-53100 3100 Siena, Italy
Citazione:
I. Ceccarelli et al., "Effects of gonadal hormones and persistent pain on non-spatial working memory in male and female rats", BEH BRA RES, 123(1), 2001, pp. 65-76

Abstract

There are indications of a modulatory role carried out by gonadal hormonesand pain in cognitive functions. We have examined this issue in male and female rats by assessing the impact of gonadectomy and persistent pain on the object recognition test. Intact and gonadectomized male and female rats were exposed to an open field (15 min) in which three objects were placed (Trial 1); the same test was repeated 2 h later (Trial 2), after the replacement of a "familiar" object with a novel one. Three days later (Day 2), the same procedure was repeated (Trial 3 and 4 with 2 h in between) but half ofthe animals were exposed to formalin-injection immediately before Trial 3. The latency, frequency and duration of approaching the three objects: wererecorded in each trial and compared by sex, gonadectomy and formalin treatment. The results showed that gonadectomized males and females had lower levels of approach to all objects and less locomotor/exploratory activity than intact animals in all experimental trials; their behaviour was not affected by repetition of the test or by pain. On Day 1, intact males showed a higher level of approach to the novel object than females. In intact males, the 2 h delay between the first and second trial failed to induce any significant modification of exploration of the novel object with respect to the familiar one, while in intact females the novel object was approached much less than the familiar one. Similarly on Day 2, the novel object was: approached for a longer time by intact males than by all the other groups. In conclusion, our data show that physiological levels of circulating gonadal hormones significantly affected the performance of male but not female rats when exposed to the object recognition test. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:46:15