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Titolo:
Footshock-induced sensitization of the acoustic startle response in two strains of mice
Autore:
Dirks, A; de Jongh, R; Groenink, L; van der Gugten, J; Hijzen, TH; Olivier, B;
Indirizzi:
Univ Utrecht, Dept Psychopharmacol, NL-3584 CA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CA 3584 CA Utrecht, Netherlands Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 123, anno: 2001,
pagine: 17 - 21
SICI:
0166-4328(20010827)123:1<17:FSOTAS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INBRED MOUSE STRAINS; FEAR-POTENTIATED STARTLE; TRAIT LOCI ANALYSES; PREPULSE INHIBITION; SHOCK SENSITIZATION; SINGLE-GENE; F1 HYBRIDS; RATS; LESIONS;
Keywords:
fear-conditioning; acoustic startle reflex; footshock; mice; sensitization; context;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Dirks, A Univ Utrecht, Dept Psychopharmacol, Sorbonnelaan 16, NL-3584 CA Utrecht, Netherlands Univ Utrecht Sorbonnelaan 16 Utrecht Netherlands NL-3584 CA ands
Citazione:
A. Dirks et al., "Footshock-induced sensitization of the acoustic startle response in two strains of mice", BEH BRA RES, 123(1), 2001, pp. 17-21

Abstract

It has been shown before that unconditioned footshocks can augment the acoustic startle response in rats. In the present study, male mice of two strains, C57BI/6N and BALB/c, were compared with regard to footshock-induced sensitization of the acoustic startle response. Presentation of footshocks did not affect the acoustic startle response in C57BI/6N mice, while in contrast, footshock-induced sensitization was apparent in the BALB/c strain. Shocked C57B1/6N mice, but not BALB/c mice, displayed robust conditioning to the startle context when re-tested the next day. These findings indicate that mice may exhibit footshock-induced sensitization of the acoustic startle response, but that the effects of footshocks on the acoustic startle are strain- and time-dependent. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 18/01/20 alle ore 10:33:28