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Titolo:
Genetic epidemiology - Approaches to the genetic analysis of rheumatoid arthritis
Autore:
John, S; Worthington, J;
Indirizzi:
Univ Manchester, ARC Epidemiol Unit, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England AstraZeneca, Macclesfield, Cheshire, England AstraZeneca Macclesfield Cheshire England acclesfield, Cheshire, England
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 4, volume: 3, anno: 2001,
pagine: 216 - 220
SICI:
1465-9913(2001)3:4<216:GE-ATT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX TRAITS; LINKAGE; REGION; ASSOCIATION; DISEASES; POLYMORPHISMS; LOCUS;
Keywords:
genetic analysis; rheumatoid arthritis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Worthington, J Univ Manchester, ARC Epidemiol Unit, Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester Stopford Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
S. John e J. Worthington, "Genetic epidemiology - Approaches to the genetic analysis of rheumatoid arthritis", ARTHRITIS R, 3(4), 2001, pp. 216-220

Abstract

The basis of susceptibility to rheumatoid arthritis (RA) is complex, comprising genetic and environmental susceptibility factors. We have reviewed the available approaches to the investigation of the genetic basis of complexdiseases and how these are being applied to RA. Affected-sibling-pair methods for nonparametric linkage analysis, linkage-disequilibrium-based approaches, transmission disequilibrium testing, and disease-association studies are discussed. The pros, cons, and limitations of the approaches are considered and are illustrated by examples from the literature about rheumatoid arthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:54:15