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Titolo:
A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" byWim B van den Berg
Autore:
Brennan, FM;
Indirizzi:
Imperial Coll Sch Med, Kennedy Inst Rheumatol Div, London W6, England Imperial Coll Sch Med London England W6 heumatol Div, London W6, England
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 4, volume: 3, anno: 2001,
pagine: 211 - 213
SICI:
1465-9913(2001)3:4<211:AFT"TI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; INTERLEUKIN-1 RECEPTOR ANTAGONIST; COLLAGEN-INDUCED ARTHRITIS; RHEUMATOID-ARTHRITIS; TNF-ALPHA; TRANSGENIC MICE; BLOCKADE; METHOTREXATE; ANTIBODIES; MODULATION;
Keywords:
anti-TNF; IL-1; IL-1ra; rheumatoid arthritis; TNF;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Brennan, FM Imperial Coll Sch Med, Kennedy Inst Rheumatol Div, 1 Aspenlea Rd, London W6, England Imperial Coll Sch Med 1 Aspenlea Rd London England W6 England
Citazione:
F.M. Brennan, "A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" byWim B van den Berg", ARTHRITIS R, 3(4), 2001, pp. 211-213

Abstract

In recent years, the effectiveness of anti-TNF therapy in treating rheumatoid arthritis (RA) has become apparent. While trials of IL-1 receptor antagonist in RA have been encouraging, it clearly is more difficult to target two molecules (IL-1 alpha and beta) than one (TNF-alpha). In his review article, Professor Wim van den Berg argues that both TNF-alpha and IL-1 must beblocked in RA and that although TNF is clearly a potent inflammatory molecule, the dominant cytokine in the subsequent degradation of the joint tissue is IL-1.This commentary discusses his hypothesis in light of animal studies and the limitations of the conclusions that can be drawn from them. Morebroadly, it discusses the biology of TNF-alpha and IL-1 and suggests explanations of why TNF-alpha is a pivotal cytokine in this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:14:49