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Titolo:
Links between complement deficiency and apoptosis
Autore:
Botto, M;
Indirizzi:
Imperial Coll Sch Med, Div Med, Rheumatol Sect, London W12 0NN, England Imperial Coll Sch Med London England W12 0NN ct, London W12 0NN, England
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 4, volume: 3, anno: 2001,
pagine: 207 - 210
SICI:
1465-9913(2001)3:4<207:LBCDAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; MOUSE PERITONEAL-MACROPHAGES; SYSTEMIC LUPUS-ERYTHEMATOSUS; DENDRITIC CELLS; VITRONECTIN RECEPTOR; CUTTING EDGE; IN-VITRO; PHAGOCYTOSIS; RECOGNITION; PHOSPHATIDYLSERINE;
Keywords:
apoptosis; complement; deficiency; SLE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Botto, M Imperial Coll Sch Med, Div Med, Rheumatol Sect, Hammersmith Campus,Du CaneRd, London W12 0NN, England Imperial Coll Sch Med Hammersmith Campus,Du Cane Rd London England W12 0NN
Citazione:
M. Botto, "Links between complement deficiency and apoptosis", ARTHRITIS R, 3(4), 2001, pp. 207-210

Abstract

Deficiency in the classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). In addition, SLE causes consumption of complement. C1q- and C4-deficient mice develop a lupus-like disease and exhibit impaired clearance of apoptotic cells. The autoantigens targeted in SLE have been localised to the surface of apoptotic cells, which may be the source of these antigens. Although apoptosis was originally thought to be an immunologically inert process,dendritic cells can present epitopes derived from apoptotic cells, and immunization with apoptotic cells leads to the generation of autoantibodies. These findings taken together indicate that a defect in complement-dependentclearance of apoptotic cells may increase susceptibility to the development of autoimmunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:00:50