Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
B cells, BAFF/zTNF4, TACl, and systemic lupus erythematosus
Autore:
Dorner, T; Putterman, C;
Indirizzi:
Charite Berlin, Dept Med, D-10098 Berlin, Germany Charite Berlin Berlin Germany D-10098 Dept Med, D-10098 Berlin, Germany Charite Berlin, Dept Rheumatol, D-10098 Berlin, Germany Charite Berlin Berlin Germany D-10098 Rheumatol, D-10098 Berlin, Germany Charite Berlin, Dept Clin Immunol, D-10098 Berlin, Germany Charite BerlinBerlin Germany D-10098 n Immunol, D-10098 Berlin, Germany Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Div Rheumatol, Bronx, NY 10467 USA Montefiore Med Ctr Bronx NY USA 10467 Div Rheumatol, Bronx, NY 10467 USA
Titolo Testata:
ARTHRITIS RESEARCH
fascicolo: 4, volume: 3, anno: 2001,
pagine: 197 - 199
SICI:
1465-9913(2001)3:4<197:BCBTAS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR FAMILY; AUTOIMMUNE-DISEASE; MURINE LUPUS; KAPPA-B; RECEPTOR; MEMBER; LIGAND; TALL-1; MICE; BLYS;
Keywords:
BAFF; SLE; TACl; TNF; TNF receptor superfamily;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Dorner, T Charite Berlin, Dept Med, Schumannstr 20-21, D-10098 Berlin, Germany Charite Berlin Schumannstr 20-21 Berlin Germany D-10098 Germany
Citazione:
T. Dorner e C. Putterman, "B cells, BAFF/zTNF4, TACl, and systemic lupus erythematosus", ARTHRITIS R, 3(4), 2001, pp. 197-199

Abstract

B cells and B-cell/T-cell collaborations are instrumental in the pathophysiology of systemic lupus erythematosus (SLE). This commentary highlights inparticular the newly discovered role of B-cell-activating factor (BAFF; also known as TALL-1, THANK, BlyS, and zTNF4) as a positive regulator of B-cell functions, such as B-cell activation and differentiation. Two members ofthe tumor necrosis factor(TNF)-receptor superfamily were recently identified as receptors for BAFF on B cells. The interaction between BAFF and its receptors may be important in the pathogenesis of lupus. Advances in our understanding of abnormalities in immune regulation in lupus might provide theopportunity to improve our current therapeutic approaches to this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:34:12