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Titolo:
Changes in plasma triglyceride levels shift lipoprotein(a) density in parallel with that of LDL independently of apolipoprotein(a) size
Autore:
Nakajima, K; Hinman, J; Pfaffinger, D; Edelstein, C; Scanu, AM;
Indirizzi:
Univ Chicago, Dept Med, Chicago, IL 60637 USA Univ Chicago Chicago IL USA60637 hicago, Dept Med, Chicago, IL 60637 USA Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA Univ ChicagoChicago IL USA 60637 ochem & Mol Biol, Chicago, IL 60637 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 7, volume: 21, anno: 2001,
pagine: 1238 - 1243
SICI:
1079-5642(200107)21:7<1238:CIPTLS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LP(A) DENSITY; ALLELES; LP; RISK;
Keywords:
hypertriglyceridemia; lipoprotein(a) density; LDL density; apolipoprotein(a) size polymorphism; lipoprotein(a) cardiovascular pathogenicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Scanu, AM Univ Chicago, Dept Med, 5841 S Maryland Ave,MC 5041, Chicago, IL60637 USA Univ Chicago 5841 S Maryland Ave,MC 5041 Chicago IL USA 60637 SA
Citazione:
K. Nakajima et al., "Changes in plasma triglyceride levels shift lipoprotein(a) density in parallel with that of LDL independently of apolipoprotein(a) size", ART THROM V, 21(7), 2001, pp. 1238-1243

Abstract

Lipoprotein(a) [Lp(a)] represents a class of low density lipoprotein (LDL particles that have as a protein moiety apolipoprotein B-100-linked covalently to a single molecule of apolipoprotein(a) [apo(a)], a specific multikringle protein of the plasminogen family. Lp(a) is polymorphic in density because of either the density heterogeneity of constitutive LDL, apo(a) size, or both. Authentic LDL also represents a set of heterogeneous particles whose density is affected by metabolic events. Whether in vivo these events may also affect Lp(a) density is not clearly established. To this effect, we studied 75 subjects with plasma Lp(a) protein levels between 7 and 50 mg/dL, and containing a single apo(a) size isoform. We used density gradient ultracentrifugation to simultaneously monitor the changes in the peak density of LDL and Lp(a) at entry and during the course of treatments directed at reducing plasma triglyceride levels. In each case, we found that at entry, Lp(a) peak density was correlated with LDL peak density (r=0.71, P <0.0001) and that during treatment, changes in plasma triglycerides were associated with shifts of Lp(a) peak density that paralleled those of LDL peak density. A high correlation (r=0.94, P <0.0001) was particularly evident in subjects with initial plasma triglycerides in the 300-mg/dL range. In vitro assembly studies showed that an apo(a) isoform containing 14 kringle IV type 2 repeats, exhibited, on incubation with LDL, a comparable degree of incorporation into LDL species varying in density between 1.035 and 1.057 g/mL Takentogether, our results indicate that metabolically dependent changes in thepeak density of Lp(a) can occur independently of apo(a) size. These changes may have to be taken into account in assessing the cardiovascular pathogenicity of this lipoprotein particle in hypertriglyceridemic subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:32:58