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Titolo:
Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women
Autore:
de Roos, NM; Bots, ML; Katan, MB;
Indirizzi:
Univ Wageningen & Res Ctr, Div Human Nutr & Epidemiol, NL-6703 HD Wageningen, Netherlands Univ Wageningen & Res Ctr Wageningen Netherlands NL-6703 HD Netherlands Wageningen Ctr Food Sci, Wageningen, Netherlands Wageningen Ctr Food Sci Wageningen Netherlands Wageningen, Netherlands Univ Utrecht, Med Ctr, Julius Ctr Patient Oriented Res, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands ent Oriented Res, Utrecht, Netherlands
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 7, volume: 21, anno: 2001,
pagine: 1233 - 1237
SICI:
1079-5642(200107)21:7<1233:RODSFA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; HIGH-DENSITY-LIPOPROTEIN; FLOW-MEDIATED DILATATION; BRACHIAL-ARTERY; VITAMIN-E; HEART-DISEASE; ANTIOXIDANT VITAMINS; VASCULAR REACTIVITY; DEPENDENT DILATION; DIABETES-MELLITUS;
Keywords:
lipoproteins; HDL; trans fatty acids; endothelium; arteriosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Katan, MB Univ Wageningen & Res Ctr, Div Human Nutr & Epidemiol, Bomenweg 2, NL-6703HD Wageningen, Netherlands Univ Wageningen & Res Ctr Bomenweg 2 Wageningen Netherlands NL-6703 HD
Citazione:
N.M. de Roos et al., "Replacement of dietary saturated fatty acids by trans fatty acids lowers serum HDL cholesterol and impairs endothelial function in healthy men and women", ART THROM V, 21(7), 2001, pp. 1233-1237

Abstract

We tested whether trans fatty acids and saturated fatty acids had different effects on flow-mediated vasodilation (FMD), a risk marker of coronary heart disease (CHD). Consumption of trans fatty acids is related to increasedrisk of CHD, probably through effects on lipoproteins. Trans fatty acids differ from most saturated fatty acids because they decrease serum high-density lipoprotein (HDL) cholesterol, and this may increase the risk of CHD. We fed 29 volunteers 2 controlled diets in a 2X4-week randomized crossover design. The "Trans-diet" contained 9.2 energy percent of trans fatty acids; these were replaced by saturated fatty acids in the "Sat-diet. " Mean serum HDL cholesterol after the Trans-diet was 0.39 mmol/L (14.8 mg/dL), or 21% lower than after the Sat-diet (95% CI 0.28 to 0.50 mmol/L). Serum low density lipoprotein and triglyceride concentrations were stable. FMD+SD was 4.4 +/-2.3% after the Trans-diet and 6.2 +/-3.0% after the Sat-diet (difference -1.8%, 95% CI -3.2 to -0.4). Replacement of dietary saturated fatty acids by trans fatty acids impaired FMD of the brachial artery, which suggests increased risk of CHD. Further studies are needed to test whether the decreasein serum HDL cholesterol caused the impairment of FMD.

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Documento generato il 03/04/20 alle ore 07:42:46