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Titolo:
Folate improves endothelial function in coronary artery disease - An effect mediated by reduction of intracellular superoxide?
Autore:
Doshi, SN; McDowell, IFW; Moat, SJ; Lang, D; Newcombe, RG; Kredan, MB; Lewis, MJ; Goodfellow, J;
Indirizzi:
Univ Wales, Coll Med, Wales Heart Res Inst, Cardiovasc Res Grp,Dept Cardiol, Cardiff CF14 4XN, S Glam, Wales Univ Wales Cardiff S Glam Wales CF14 4XN Cardiff CF14 4XN, S Glam, Wales Univ Wales, Coll Med, Wales Heart Res Inst, Cardiovasc Res Grp,Dept Biochem, Cardiff CF14 4XN, S Glam, Wales Univ Wales Cardiff S Glam Wales CF14 4XN Cardiff CF14 4XN, S Glam, Wales Univ Wales, Coll Med, Wales Heart Res Inst, Cardiovasc Res Grp,Dept Pharmacol, Cardiff CF14 4XN, S Glam, Wales Univ Wales Cardiff S Glam Wales CF14 4XN Cardiff CF14 4XN, S Glam, Wales Univ Wales, Coll Med, Dept Med Comp & Stat, Cardiff CF14 4XN, S Glam, Wales Univ Wales Cardiff S Glam Wales CF14 4XN Cardiff CF14 4XN, S Glam, Wales
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 7, volume: 21, anno: 2001,
pagine: 1196 - 1202
SICI:
1079-5642(200107)21:7<1196:FIEFIC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ORAL METHIONINE LOAD; FOLIC-ACID; PLASMA HOMOCYSTEINE; ANTIOXIDANT CAPACITY; LIPID-PEROXIDATION; VASCULAR-DISEASE; OXIDATIVE STRESS; RISK FACTOR; HYPERHOMOCYSTEINEMIA;
Keywords:
folic acid; homocysteine; coronary artery disease; endothelial function; 5-methyltetrahydrofolate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Goodfellow, J Univ Wales, Coll Med, Wales Heart Res Inst, Cardiovasc Res Grp,Dept Cardiol, Heath Pk, Cardiff CF14 4XN, S Glam, Wales Univ Wales HeathPk Cardiff S Glam Wales CF14 4XN lam, Wales
Citazione:
S.N. Doshi et al., "Folate improves endothelial function in coronary artery disease - An effect mediated by reduction of intracellular superoxide?", ART THROM V, 21(7), 2001, pp. 1196-1202

Abstract

Homocysteine is a risk factor for coronary artery disease (CAD). Folic acid lowers homocysteine and may improve endothelial function in CAD, althoughthe mechanism is unclear. We investigated the effect of folic acid on endothelial function, homocysteine, and oxidative stress in patients with CAD. We also examined the acute effect of 5-methyltetrahydrofolate (5-MTHF), theprincipal circulating folate, on endothelial function in vivo and on intracellular superoxide in cultured endothelial cells. A randomized crossover study of folic acid (5 mg daily) for 6 weeks was undertaken in 52 patients with CAD. Ten further patients were given intra-arterial 5-MTHF, Endothelialfunction was assessed by flow-mediated dilatation (FMD). Folic acid increased plasma folate (P <0.001), lowered homocysteine by 19% (P <0.001), and improved FMD (P <0.001). FMD improvement did not correlate with homocysteinereduction. Malondialdehyde and total plasma antioxidant capacity, markers of oxidative stress, were unchanged. 5-MTHF acutely improved FMD (P <0.001)without altering homocysteine (P=0.47). In vitro, 5-MTHF abolished homocysteine-induced intracellular superoxide increase (P <0.001); this effect wasalso observed with folic acid and tetrahydrobiopterin. Our data support the beneficial effect of folic acid on endothelial function in CAD but suggest that the mechanism is independent of homocysteine. Reduction of intracellular endothelial superoxide may have contributed to the effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:21:01