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Titolo:
Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis
Autore:
Pepper, MS;
Indirizzi:
Ctr Med Univ Geneva, Dept Morphol, CH-1211 Geneva 4, Switzerland Ctr Med Univ Geneva Geneva Switzerland 4 , CH-1211 Geneva 4, Switzerland
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 7, volume: 21, anno: 2001,
pagine: 1104 - 1117
SICI:
1079-5642(200107)21:7<1104:ROTMMA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; TUMOR-NECROSIS-FACTOR; UROKINASE RECEPTOR EXPRESSION; DISTINCT ANTITUMOR PROPERTIES; BASEMENT-MEMBRANE COLLAGEN; LEWIS-LUNG-CARCINOMA; MIDDLE T-ONCOGENE; CELLS IN-VITRO; GELATINASE-A; PROTEOLYTIC ACTIVITY;
Keywords:
extracellular matrix; endothelium; metalloproteinase; plasminogen; cancer;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
169
Recensione:
Indirizzi per estratti:
Indirizzo: Pepper, MS Ctr Med Univ Geneva, Dept Morphol, 1 Rue Michel Servet, CH-1211Geneva 4, Switzerland Ctr Med Univ Geneva 1 Rue Michel Servet Geneva Switzerland 4 d
Citazione:
M.S. Pepper, "Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis", ART THROM V, 21(7), 2001, pp. 1104-1117

Abstract

Extracellular proteolysis is an absolute requirement for new blood vessel formation (angiogenesis). This review examines the role of the matrix metalloproteinase (MMP) and plasminogen activator (PA)-plasmin systems during angiogenesis. Specifically, a role for gelatinases (MMP-2, MMP-9), membrane-type 1 MMP (MMP-14), the urokinase-type PA receptor, and PA inhibitor I has been clearly defined in a number of model systems. The MMP and PA-plasmin systems have also been implicated in experimental vascular tumor formation, and their role during this process will be examined. Antiproteolysis, particularly in the context of angiogenesis, has become a key target in therapeutic strategies aimed at inhibiting tumor growth and other diseases associated with neovascularization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 12:51:33