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Titolo:
Effects of aerosol-vapor JP-8 jet fuel on the functional observational battery, and learning and memory in the rat
Autore:
Baldwin, CM; Houston, FP; Podgornik, MN; Young, RS; Barnes, CA; Witten, ML;
Indirizzi:
Univ Arizona, Coll Med, Dept Med, Resp Sci Ctr,Div Resp Sci, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 i Ctr,Div Resp Sci, Tucson, AZ 85724 USA So Arizona Vet Affairs Hlth Care Syst, Dept Psychiat, Tucson, AZ USA So Arizona Vet Affairs Hlth Care Syst Tucson AZ USA hiat, Tucson, AZ USA Univ Arizona, Div Neural Syst Memory & Aging, Arizona Res Labs, Tucson, AZUSA Univ Arizona Tucson AZ USA mory & Aging, Arizona Res Labs, Tucson, AZUSA Univ Arizona, Coll Med, Dept Pediat, Joan B & Donald R Diamond Lung InjuryLab, Tucson, AZ USA Univ Arizona Tucson AZ USA nald R Diamond Lung InjuryLab, Tucson, AZ USA
Titolo Testata:
ARCHIVES OF ENVIRONMENTAL HEALTH
fascicolo: 3, volume: 56, anno: 2001,
pagine: 216 - 226
SICI:
0003-9896(200105/06)56:3<216:EOAJJF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-DEPENDENT SENSITIZATION; FISCHER-344 RATS; EXPOSURE; MICE; AMPHETAMINE; LOCOMOTION; MECHANISMS; RESPONSES; TOXICITY; BEHAVIOR;
Keywords:
aerosol vapor; Functional Observational Battery; JP-8 jet fuel; learning; memory; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Baldwin, CM Univ Arizona, Coll Med, Dept Med, Resp Sci Ctr,Div Resp Sci, Room 2336,1501 N Campbell Ave, Tucson, AZ 85724 USA Univ Arizona Room 2336,1501 N Campbell Ave Tucson AZ USA 85724
Citazione:
C.M. Baldwin et al., "Effects of aerosol-vapor JP-8 jet fuel on the functional observational battery, and learning and memory in the rat", ARCH ENV HE, 56(3), 2001, pp. 216-226

Abstract

To determine whether JP-8 jet fuel affects parameters of the Functional Observational Battery (FOB), visual discrimination, or spatial Learning and memory, the authors exposed groups of male Fischer Brown Norway hybrid rats for 28 d to aerosol/vapor-delivered JP-8, or to JP-8 followed by 15 min of aerosolized substance P analogue, or to sham-confined fresh room air. Behavioral testing was accomplished with the U.S. Environmental Protection Agency's Functional Observational Battery. The authors used the Morris swim taskto test visual and spatial learning and memory testing. The spatial test included examination of memory for the original target location following 15d of JP-8 exposure, as well as a 3-d new target location learning paradigmimplemented the day that followed the final day of exposure. Only JP-8 exposed animals had significant weight loss by the 2nd week of exposure compared with JP-8 with substance P and control rats; this finding compares with those of prior studies of JP-8 jet fuel. Rats exposed to JP-8 with or without substance P exhibited significantly greater rearing and less grooming behavior over time than did controls during Functional Observational Battery open-field testing. Exposed rats also swam significantly faster than controls during the new target location training and testing, thus supporting theincreased activity noted during Functional Observational Battery testing. There were no significant differences between the exposed and control groups' performances during acquisition, retention, or learning of the new platform location in either the visual discrimination or spatial version of the Morris swim task. The data suggest that although visual discrimination and spatial learning and memory were not disrupted by JP-8 exposure, arousal indices and activity measures were distinctly different in these animals.

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Documento generato il 27/01/21 alle ore 02:52:39