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Titolo:
Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
Autore:
Meaney, MJ;
Indirizzi:
McGill Univ, Douglas Hosp, Res Ctr, Dept Psychiat,Dev Neuroendocrinol Lab,Montreal, PQ, Canada McGill Univ Montreal PQ Canada Neuroendocrinol Lab,Montreal, PQ, Canada McGill Univ, McGill Ctr Study Behav Genes & Environm, Montreal, PQ, CanadaMcGill Univ Montreal PQ Canada av Genes & Environm, Montreal, PQ, Canada
Titolo Testata:
ANNUAL REVIEW OF NEUROSCIENCE
, volume: 24, anno: 2001,
pagine: 1161 - 1192
SICI:
0147-006X(2001)24:<1161:MCGEAT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CEREBROSPINAL-FLUID CONCENTRATIONS; CORTICOSTEROID RECEPTOR BALANCE; PITUITARY-ADRENAL RESPONSES; MESSENGER-RNA EXPRESSION; ACOUSTIC STARTLE REFLEX; BINDING GLOBULIN LEVELS; LONG-TERM POTENTIATION;
Keywords:
corticotropin-releasing factor (hormone); gene expression; hippocampal development; oxytocin receptors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
203
Recensione:
Indirizzi per estratti:
Indirizzo: Meaney, MJ McGill Univ, Douglas Hosp, Res Ctr, Dept Psychiat,Dev Neuroendocrinol Lab,Montreal, PQ, Canada McGill Univ Montreal PQ Canada rinol Lab,Montreal, PQ, Canada
Citazione:
M.J. Meaney, "Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations", ANN R NEUR, 24, 2001, pp. 1161-1192

Abstract

Naturally occurring variations in maternal care alter the expression of genes that regulate behavioral and endocrine responses to stress, as well as hippocampal synaptic development. These effects form the basis for the development of stable, individual differences in stress reactivity and certain forms of cognition. Maternal care also influences the maternal behavior of female offspring, an effect that appears to be related to oxytocin receptorgene expression, and which forms the basis for the intergenerational transmission of individual differences in stress reactivity. Patterns of maternal care that increase stress reactivity in offspring are enhanced by stressors imposed on the mother. These findings provide evidence for the importance of parental care as a mediator of the effects of environmental adversity on neural development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 14:35:46