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Titolo:
To eat or to sleep? Orexin in the regulation of feeding and wakefulness
Autore:
Willie, JT; Chemelli, RM; Sinton, CM; Yanagisawa, M;
Indirizzi:
Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 ward Hughes Med Inst, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Ctr, Dept Mol Genet, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Med Ctr, Dept Pediat, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 d Ctr, Dept Psychiat, Dallas, TX 75390 USA
Titolo Testata:
ANNUAL REVIEW OF NEUROSCIENCE
, volume: 24, anno: 2001,
pagine: 429 - 458
SICI:
0147-006X(2001)24:<429:TEOTSO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATERAL HYPOTHALAMIC AREA; MELANIN-CONCENTRATING HORMONE; RECEPTOR MESSENGER-RNA; ADULT-RAT BRAIN; NEUROPEPTIDE-Y; HYPOCRETIN OREXIN; FOOD-INTAKE; BODY-WEIGHT; PREPRO-OREXIN; SELF-STIMULATION;
Keywords:
appetite; metabolism; arousal; narcolepsy; lateral hypothalamus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: Willie, JT Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Med Inst, Dallas, TX 75390 USA
Citazione:
J.T. Willie et al., "To eat or to sleep? Orexin in the regulation of feeding and wakefulness", ANN R NEUR, 24, 2001, pp. 429-458

Abstract

Orexin-A and orexin-B are neuropeptides originally identified as endogenous ligands for two orphan G-protein-coupled receptors. Orexin neuropeptides (also known as hypocretins) are produced by a small group of neurons in thelateral hypothalamic and perifornical areas, a region classically implicated in the control of mammalian feeding behavior. Orexin neurons project throughout the central nervous system (CNS) to nuclei known to be important inthe control of feeding, sleep-wakefulness, neuroendocrine homeostasis, andautonomic regulation. orexin mRNA expression is upregulated by fasting andinsulin-induced hypoglycemia. C-fos expression in orexin neurons, an indicator of neuronal activation, is positively correlated with wakefulness and negatively correlated with rapid eye movement (REM) and non-REM sleep states. Intracerebroventricular administration of orexins has been shown to significantly increase food consumption, wakefulness, and locomotor activity inrodent models. Conversely, an orexin receptor antagonist inhibits food consumption. Targeted disruption of the orexin gene in mice produces a syndrome remarkably similar to human and canine narcolepsy, a sleep disorder characterized by excessive daytime sleepiness, cataplexy, and other pathologicalmanifestations of the intrusion of REM sleep-related features into wakefulness. Furthermore, orexin knockout mice are hypophagic compared with weightand age-matched littermates, suggesting a role in modulating energy metabolism. These findings suggest that the orexin neuropeptide system plays a significant role in feeding and sleep-wakefulness regulation, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions.

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Documento generato il 23/01/20 alle ore 18:19:41