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Titolo:
Synaptic modification by correlated activity: Hebb's postulate revisited
Autore:
Bi, GQ; Poo, MM;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA
Titolo Testata:
ANNUAL REVIEW OF NEUROSCIENCE
, volume: 24, anno: 2001,
pagine: 139 - 166
SICI:
0147-006X(2001)24:<139:SMBCAH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CEREBELLAR PURKINJE-CELLS; CULTURED HIPPOCAMPAL-NEURONS; RABBIT FOLLOWING STIMULATION; DEPOLARIZING CURRENT PULSES; OCULAR DOMINANCE COLUMNS; NEURAL NETWORKS; LASTING POTENTIATION; VISUAL-CORTEX; AREA CA1;
Keywords:
Hebbian synapse; LTP; LTD; spike timing; input specificity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
177
Recensione:
Indirizzi per estratti:
Indirizzo: Bi, GQ Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 , Pittsburgh, PA 15261 USA
Citazione:
G.Q. Bi e M.M. Poo, "Synaptic modification by correlated activity: Hebb's postulate revisited", ANN R NEUR, 24, 2001, pp. 139-166

Abstract

Correlated spiking of pre- and postsynaptic neurons can result in strengthening or weakening of synapses, depending on the temporal order of spiking. Recent findings indicate that there are narrow and cell type-specific temporal windows for such synaptic modification and that the generally acceptedinput- (or synapse-) specific rule for modification appears not to be strictly adhered to. Spike timing-dependent modifications, together with selective spread of synaptic changes, provide a set of cellular mechanisms that are likely to be important for the development and functioning of neural networks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:14:36