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Titolo:
Sulfasalazine decreases acute gastrointestinal complications due to pelvicradiotherapy
Autore:
Kilic, D; Ozenirler, S; Egehan, I; Dursun, A;
Indirizzi:
Gazi Univ, Dept Radiat Oncol, Fac Med, Ankara, Turkey Gazi Univ Ankara Turkey niv, Dept Radiat Oncol, Fac Med, Ankara, Turkey Gazi Univ, Dept Gastroenterol, Fac Med, Ankara, Turkey Gazi Univ Ankara Turkey iv, Dept Gastroenterol, Fac Med, Ankara, Turkey Gazi Univ, Dept Pathol, Fac Med, Ankara, Turkey Gazi Univ Ankara TurkeyGazi Univ, Dept Pathol, Fac Med, Ankara, Turkey
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 7-8, volume: 35, anno: 2001,
pagine: 806 - 810
SICI:
1060-0280(200107/08)35:7-8<806:SDAGCD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; ULCERATIVE-COLITIS; RADIATION; OLSALAZINE; SULPHASALAZINE;
Keywords:
gastrointestinal complications; pelvic radiotherapy; sulfasalazine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kilic, D Yildiz Sancak Mah 249,Sok 19-5 Cankaya, TR-06550 Ankara, Turkey Yildiz Sancak Mah 249,Sok 19-5 Cankaya Ankara Turkey TR-06550 y
Citazione:
D. Kilic et al., "Sulfasalazine decreases acute gastrointestinal complications due to pelvicradiotherapy", ANN PHARMAC, 35(7-8), 2001, pp. 806-810

Abstract

BACKGROUND: Radiation-induced gastrointestinal toxicity is a significant concern for patients who are treated with this modality for pelvic malignancies. Eicosanoids and free radicals are thought to be among the reasons for this effect. Sulfasalazine is an inhibitor of their synthesis in the mucosa. OBJECTIVE: To determine whether sulfasalazine can reduce the radiation-induced acute gastrointestinal complications. METHODS: In this prospective, double-blind study, 31 patients receiving pelvic radiotherapy were randomized to receive two sulfasalazine 500-mg tablets twice daily or placebo, administered orally from the, first day of irradiation. Patients were evaluated weekly, and gastrointestinal toxicities were graded according to the Late Effect of Normal Tissue - Subjective Objective Management Analytic (LENT-SOMA) toxicity table during pelvic radiotherapy. On the last day of week 5, the subjects were graded endoscopically, and biopsies taken from the rectum were classified histopathologically.;RESULTS: Groups did not differ in age, gender, tumor site, or irradiation procedure. During radiotherapy, grade 2 or higher gastrointestinal toxicityoccurred in 20% (3/15) and 63% (10/16) of the sulfasalazine and placebo groups, respectively. This - difference was significant (p = 0.017). No statistically significant differences were found in endoscopic and histopathologic evaluations. CONCLUSIONS: Sulfasalazine is effective in decreasing clinically acute gastrointestinal toxicities. Long-term follow-up with the subjects will help to determine the net effect of sulfasalazine on the radiation-induced gastrointestinal injuries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 18:40:01