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Titolo:
Radiotherapy after breast-conserving surgery in small breast carcinoma: Long-term results of a randomized trial
Autore:
Veronesi, U; Marubini, E; Mariani, L; Galimberti, V; Luini, A; Veronesi, P; Salvadori, B; Zucali, R;
Indirizzi:
European Inst Oncol, Dept Senol, I-20141 Milan, Italy European Inst OncolMilan Italy I-20141 Dept Senol, I-20141 Milan, Italy Ist Nazl Studio & Cura Tumori, Dept Biometrics, I-20133 Milan, Italy Ist Nazl Studio & Cura Tumori Milan Italy I-20133 , I-20133 Milan, Italy Policlin San Marco, Dept Oncol, Bergamo, Italy Policlin San Marco Bergamo Italy San Marco, Dept Oncol, Bergamo, Italy Osped Clinicizzato, Dept Radiotherapy, Milan, Italy Osped Clinicizzato Milan Italy cizzato, Dept Radiotherapy, Milan, Italy
Titolo Testata:
ANNALS OF ONCOLOGY
fascicolo: 7, volume: 12, anno: 2001,
pagine: 997 - 1003
SICI:
0923-7534(200107)12:7<997:RABSIS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARING TOTAL MASTECTOMY; RADIATION-THERAPY; CLINICAL-TRIAL; AXILLARY DISSECTION; CANCER; IRRADIATION; LUMPECTOMY; RESECTION; SURVIVAL;
Keywords:
breast-conserving surgery; radiotherapy; small breast carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Veronesi, U European Inst Oncol, Dept Senol, Via G Ripamonti 435, I-20141 Milan, Italy European Inst Oncol Via G Ripamonti 435 Milan Italy I-20141 y
Citazione:
U. Veronesi et al., "Radiotherapy after breast-conserving surgery in small breast carcinoma: Long-term results of a randomized trial", ANN ONCOL, 12(7), 2001, pp. 997-1003

Abstract

Background: Breast-conserving surgery followed by radiotherapy is a widelyaccepted form of treatment in patients with breast cancer of limited extent. Many attempts have been made to identify subgroups of patients who mightavoid radiotherapy. Patients and methods: Between 1987 and 1989, 579 women with carcinoma of the breast were randomly assigned to quadrantectomy, axillary dissection andradiotherapy (299) and to quadrantectomy with axillary dissection without radiotherapy (280). Eligible patients were women with a breast carcinoma less than 2.5 cm in maximum diameter up to 70 years of age. Primary endpointswere intra-breast tumour reappearance (IBTR) and all-cause mortality. Results: The number of IBTRs was significantly higher in patients treated with surgery alone (59 cases out of 273; 10-year crude cumulative incidenceof 23.5%) than in patients treated with surgery plus radiotherapy (16 cases out of 294; 10-year crude cumulative incidence of 5.8%). The difference in IBTR frequency between the two treatments appeared to be particularly high in women up to 45 years of age, tending to decrease with increasing age up to no apparent difference in women older than 65 years. Overall survival curves for the two groups, did not differ significantly (P = 0.326). However, a limited survival advantage was evident after radiotherapy for node-positive women. Conclusions: After breast-conserving surgery radiotherapy appears indicated in all patients up to 55 years of age, in patients with positive axillarynodes, and in patients with extensive intraductal component at histology. The data suggest that radiotherapy may be avoided in patients older than 65, and may be optional in women aged 56-65 years with negative nodes.

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Documento generato il 28/03/20 alle ore 23:31:24