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Titolo:
Analytical method based on room-temperature phosphorimetry for the determination of rescinamine in pharmaceutical tablets
Autore:
Aucelio, RQ;
Indirizzi:
Pontificia Univ Catolica Rio de Janeiro, Dept Quim, BR-22453900 Rio De Janeiro, RJ, Brazil Pontificia Univ Catolica Rio de Janeiro Rio De Janeiro RJBrazil BR-22453900 BC
Titolo Testata:
ANALYTICAL SCIENCES
fascicolo: 7, volume: 17, anno: 2001,
pagine: 865 - 868
SICI:
0910-6340(200107)17:7<865:AMBORP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; LOW-BACKGROUND PAPER; FLUOROMETRIC-DETERMINATION; YOHIMBINE HYDROCHLORIDE; ANTIHYPERTENSIVE DRUGS; HEAVY-ATOM; RESERPINE; PHOSPHORESCENCE; FORMULATIONS; CARBARYL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Aucelio, RQ Pontificia Univ Catolica Rio de Janeiro, Dept Quim, BR-22453900 Rio De Janeiro, RJ, Brazil Pontificia Univ Catolica Rio de Janeiro Rio De Janeiro RJ Brazil BR-22453900 BC
Citazione:
R.Q. Aucelio, "Analytical method based on room-temperature phosphorimetry for the determination of rescinamine in pharmaceutical tablets", ANAL SCI, 17(7), 2001, pp. 865-868

Abstract

An analytical method based on solid surface room temperature phosphorescence (SSRTP) for the determination of rescinamine was developed. Signal enhancements were obtained by heavy atom effect, use of surfactant agent and useof basic medium. Alternatively, an ultraviolet treatment of the analyte was tried in order to induce a phosphor with higher phosphorescence quantum efficiency. A limit of detection of 2.70 ng and linear dynamic range of 2 orders of magnitude were achieved in paper substrate treated for background reduction. A study was performed to verify potential interferences of several pharmacological active ingredients that could be associated with rescinamine in a pharmaceutical preparation. The method was tested by analyzing rescinamine in three different laboratory-made tablets.

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Documento generato il 20/01/20 alle ore 10:19:40