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Titolo:
Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height
Autore:
Hirschhorn, JN; Lindgren, CM; Daly, MJ; Kirby, A; Schaffner, SF; Burtt, NP; Altshuler, D; Parker, A; Rioux, JD; Platko, J; Gaudet, D; Hudson, TJ; Groop, LC; Lander, ES;
Indirizzi:
MIT, Whitehead Ctr Genome Res, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 tehead Ctr Genome Res, Cambridge, MA 02139 USA MIT, Dept Biol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Biol, Cambridge, MA 02139 USA Millennium Pharmaceut Inc, Dept Genet, Cambridge, England Millennium Pharmaceut Inc Cambridge England t Genet, Cambridge, England Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 , Div Endocrinol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pediat, Boston, MA 02115 USA Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Dept Med, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Genet, Boston, MA 02114 USA Massachusetts GenHosp Boston MA USA 02114 pt Genet, Boston, MA 02114 USA Univ Lund, Dept Endocrinol, Malmo, Sweden Univ Lund Malmo SwedenUniv Lund, Dept Endocrinol, Malmo, Sweden Ctr Hosp Univ Montreal, Chicoutimi Hosp, Prevent Genet & Community Genet Ctr, Montreal, PQ, Canada Ctr Hosp Univ Montreal Montreal PQ Canada enet Ctr, Montreal, PQ, Canada McGill Univ, Ctr Hlth, Montreal Genome Ctr, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Montreal Genome Ctr, Montreal, PQ, Canada
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 1, volume: 69, anno: 2001,
pagine: 106 - 116
SICI:
0002-9297(200107)69:1<106:GLAOSI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE; QUANTITATIVE TRAITS; VARIANCE-COMPONENTS; HIP FRACTURE; BODY HEIGHT; POLYMORPHISM; CHILDREN; WOMEN; RISK; PEDIGREES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Hirschhorn, JN MIT, Whitehead Ctr Genome Res, 1 Kendall Sq, Cambridge, MA 02139 USA MIT 1 Kendall Sq Cambridge MA USA 02139 ridge, MA 02139 USA
Citazione:
J.N. Hirschhorn et al., "Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height", AM J HU GEN, 69(1), 2001, pp. 106-116

Abstract

Genomewide linkage analysis has been extremely successful at identification of the genetic variation underlying single-gene disorders. However, linkage analysis has been less successful for common human diseases and other complex traits in which multiple genetic and environmental factors interact to influence disease risk. We hypothesized that a highly heritable complex trait, in which the contribution of environmental factors was relatively limited, might be more amenable to linkage analysis. We therefore chose to study stature (adult height), for which heritability is 75%-90% (Phillips and Matheny 1990; Carmichael and McGue 1995; Preece 1996; Silventoinen et al. 2000). We reanalyzed genomewide scans from four populations for which genotype and height data were available, using a variance-components method implemented in GENEHUNTER 2.0 (Pratt et al. 2000). The populations consisted of 408 individuals in 58 families from the Botnia region of Finland, 753 individuals in 183 families from other parts of Finland, 746 individuals in 179 families from Southern Sweden, and 420 individuals in 63 families from the Saguenay-Lac-St.-Jean region of Quebec. Four regions showed evidence of linkage to stature: 6q24-25, multipoint LOD score 3.85 at marker D6S1007 in Botnia (genomewide P<.06), 7q31.3-36 (LOD 3.40 at marker D7S2195 in Sweden, P<.02), 12p11.2-q14 (LOD 3.35 at markers D12S10990-D12S398 in Finland,P<.05)and 13q32-33 (LOD 3.56 at markers D13S779-D13S797 in Finland, P<.05). In acompanion article (Perola et al. 2001 [in this issue]), strong supporting evidence is obtained for linkage to the region on chromosome 7. These studies suggest that highly heritable complex traits such as stature may be genetically tractable and provide insight into the genetic architecture of complex traits.

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Documento generato il 01/04/20 alle ore 23:41:29