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Titolo:
A genomewide screen for autism susceptibility loci
Autore:
Liu, JJ; Nyholt, DR; Magnussen, P; Parano, E; Pavone, P; Geschwind, D; Lord, C; Iversen, P; Hoh, J; Ott, J; Gilliam, TC;
Indirizzi:
Columbia Univ, Columbia Genome Ctr, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ia Genome Ctr, New York, NY 10032 USA Columbia Univ, Dept Psychiat, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Dept Psychiat, New York, NY 10032 USA Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ NewYork NY USA 10032 t Genet & Dev, New York, NY 10032 USA Rockefeller Univ, Lab Stat Genet, New York, NY 10021 USA Rockefeller UnivNew York NY USA 10021 Stat Genet, New York, NY 10021 USA Univ Catania, Dept Pediat, I-95124 Catania, Italy Univ Catania Catania Italy I-95124 , Dept Pediat, I-95124 Catania, Italy Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 o, Dept Psychiat, Chicago, IL 60637 USA Cure Autism Now Fdn, Los Angeles, CA USA Cure Autism Now Fdn Los Angeles CA USA tism Now Fdn, Los Angeles, CA USA
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 2, volume: 69, anno: 2001,
pagine: 327 - 340
SICI:
0002-9297(200108)69:2<327:AGSFAS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIB-PAIR LINKAGE; PERVASIVE DEVELOPMENTAL DISORDERS; GENETICALLY COMPLEX TRAITS; AFFECTED RELATIVE PAIRS; SEROTONIN TRANSPORTER; GENOMIC SCREEN; CHROMOSOME; STRATEGIES; CHILDREN; MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Gilliam, TC Columbia Univ, Columbia Genome Ctr, 1150 St Nicholas Ave,Room 508, New York, NY 10032 USA Columbia Univ 1150 St Nicholas Ave,Room 508 NewYork NY USA 10032
Citazione:
J.J. Liu et al., "A genomewide screen for autism susceptibility loci", AM J HU GEN, 69(2), 2001, pp. 327-340

Abstract

We report the analysis of 335 microsatellite markers genotyped in 110 multiplex families with autism. All families include at least two "affected" siblings, at least one of whom has autism; the remaining affected sibs carry diagnoses of either Asperger syndrome or pervasive developmental disorder. Affected sib-pair analysis yielded multipoint maximum LOD scores (MLS) thatreach the accepted threshold for suggestive linkage on chromosomes 5, X, and 19. Nominal evidence for linkage (point-wise) was obtained on chromosomes 2, 3, 4, 8, 10, 11, 12, 15, 16, 18, and 20, and secondary loci were foundon chromosomes 5 and 19. Analysis of families sharing alleles at the putative X chromosomal linked locus and one or more other putative linked loci produced an MLS of 3.56 for the DXS470-D19S174 marker combination. In an effort to increase power to detect linkage, scan statistics were used to evaluate the significance of peak LOD scores based on statistical evidence at adjacent marker loci. This analysis yielded impressive evidence for linkage to autism and autism-spectrum disorders with significant genome-wide P values <.05 for markers on chromosomes 5 and 8 and with suggestive linkage evidence for a marker on chromosome 19.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 12:00:53