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Titolo:
Changes in ethanol preference by rats treated with gamma 1 and gamma 2 GABA(A) receptor subunit antisense oligodeoxynucleotides
Autore:
Malatynska, E; Dyr, W; Krzascik, P; Kostowski, W;
Indirizzi:
Indiana Univ Sch Med, Dept Pharmacol & Toxicol, Evansville, IN 47712 USA Indiana Univ Sch Med Evansville IN USA 47712 ol, Evansville, IN 47712 USA Indiana Univ Sch Med, Dept Psychiat, Evansville, IN 47712 USA Indiana UnivSch Med Evansville IN USA 47712 at, Evansville, IN 47712 USA Inst Psychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, PL-02957 Warsaw, Poland Inst Psychiat & Neurol Warsaw Poland PL-02957 t, PL-02957 Warsaw, Poland Med Acad, Dept Expt & Clin Pharmacol, PL-00927 Warsaw, Poland Med Acad Warsaw Poland PL-00927 Clin Pharmacol, PL-00927 Warsaw, Poland
Titolo Testata:
ALCOHOL AND ALCOHOLISM
fascicolo: 4, volume: 36, anno: 2001,
pagine: 309 - 313
SICI:
0735-0414(200107/08)36:4<309:CIEPBR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITORY POSTSYNAPTIC CURRENTS; STIMULATED CL-36(-) INFLUX; CEREBRAL CORTICAL-NEURONS; AMINOBUTYRIC-ACID; DRINKING BEHAVIOR; HIPPOCAMPUS; WITHDRAWAL; CORTEX; OLIGONUCLEOTIDE; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Malatynska, E Indiana Univ Sch Med, Dept Pharmacol & Toxicol, 8600 Univ Blvd, Evansville, IN 47712 USA Indiana Univ Sch Med 8600 Univ Blvd EvansvilleIN USA 47712
Citazione:
E. Malatynska et al., "Changes in ethanol preference by rats treated with gamma 1 and gamma 2 GABA(A) receptor subunit antisense oligodeoxynucleotides", ALC ALCOHOL, 36(4), 2001, pp. 309-313

Abstract

Micro- injections (10 nmol/day over 5 days) of antisense oligodeoxynucleotides (aODNs) to gamma -aminobutyric acid A (GABA(A)) receptor alpha1 and gamma2 subunits reduce the mRNA for these subunits in rat brain. In this study, the effects of alpha1 and gamma2 subunit aODNs on rat alcohol preferencewere investigated. Reduction of the alpha1 subunit mRNA decreased, whereasreduction of the gamma2 subunit mRNA increased. ethanol intake in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:52:11