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Titolo:
Chronic high-dose nitrazepam dependence I-123-IMP SPECT and EEG studies
Autore:
Kitabayashi, Y; Ueda, H; Narumoto, J; Iizumi, H; Tsuchida, H; Murata, N; Nakajima, S; Fukui, K;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Psychiat, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 257 - 261
SICI:
1355-6215(200107)6:3<257:CHNDIS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; EMISSION COMPUTED-TOMOGRAPHY; ORBITOFRONTAL CORTEX; BENZODIAZEPINES; HALOPERIDOL; ADDICTION; ABUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Kitabayashi, Y Kyoto Prefectural Univ Med, Dept Psychiat, Kamigyo Ku, Kawaramachi Hirokoji, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kawaramachi Hirokoji Kyoto Japan 6028566
Citazione:
Y. Kitabayashi et al., "Chronic high-dose nitrazepam dependence I-123-IMP SPECT and EEG studies", ADDICT BIOL, 6(3), 2001, pp. 257-261

Abstract

A patient who took 50-100 mg nitrazepam per day for 25 years is presented. I-123-IMP SPECT (autoradiography method) and EEG were performed sequentially on the subject during and after the withdrawal syndrome. Severe hypoperfusion of the whole brain on SPECT and diffuse slow activity on EEG were demonstrated during the withdrawal syndrome and subsequently remarkably improved. However, *the hypofrontal pattern on both early and delayed images in SPECT was unchanged. The changes observed on SPECT and EEG reflect the pathophysiology of dependence and withdrawal. Additionally, the hypofrontal pattern remained unchanged suggesting that organic brain damage can develop as a result of chronic high-dose benzodiazepine abuse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:30:32