Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Information processing deficits in withdrawing alcoholics
Autore:
Keedwell, PA; Kumari, V; Poon, L; Marshall, EJ; Checkley, SA;
Indirizzi:
Inst Psychiat, London, England Inst Psychiat London EnglandInst Psychiat, London, England
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 239 - 245
SICI:
1355-6215(200107)6:3<239:IPDIWA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; PREPULSE INHIBITION; SCHIZOPHRENIC-PATIENTS; ANIMAL-MODEL; HABITUATION; STIMULATION; POPULATION; DEPENDENCE; YOHIMBINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Keedwell, PA Maudsley Hosp, Natl Alcohol Unit, Denmark Hill, London SE5 8AZ, England Maudsley Hosp Denmark Hill London England SE5 8AZ Z, England
Citazione:
P.A. Keedwell et al., "Information processing deficits in withdrawing alcoholics", ADDICT BIOL, 6(3), 2001, pp. 239-245

Abstract

Prepulse inhibition (PPI) of the acoustic startle response (a reduction inresponse to an intense, startling stimulus (the pulse) if preceded by 30-150 ms by a weaker, non-startling stimulus) is an established model to indexinformation processing deficits in thought-disordered schizophrenic patients. The present study aimed to investigate the influence of alcohol withdrawal on the PPI effect. Eight withdrawing alcoholic patients underwent testing for PPI of the acoustic startle response (defined as percentage reduction of the response over pulse-alone stimulus; prepulses 15 dB above the background) on three occasions (1, 3 and 7 days following the last drink). The results demonstrated remarkably low levels of PPI on days 1 and 3, with this being very robust in three patients who had a history of delirium tremens; there was a trend towards normalization of PPI on day 7. This study, although preliminary, suggests strongly that there is a deficit in the filtering of sensory information in alcohol-dependent patients undergoing alcohol withdrawal. This was most apparent in those with a history of delirium tremens. Further studies are needed to define the cause and chronicity of these deficits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:22:28