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Titolo:
Association between catechol-O-methyltransferase (COMT) polymorphism and severe alcoholic withdrawal symptoms in male Japanese alcoholics
Autore:
Nakamura, A; Inada, T; Kitao, Y; Katayama, Y;
Indirizzi:
Inokashira Hosp, Mitaka, Tokyo, Japan Inokashira Hosp Mitaka Tokyo JapanInokashira Hosp, Mitaka, Tokyo, Japan Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Chiba, Japan Natl Ctr Neurol & Psychiat Chiba Japan l Inst Mental Hlth, Chiba, Japan
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 3, volume: 6, anno: 2001,
pagine: 233 - 238
SICI:
1355-6215(200107)6:3<233:ABC(PA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE TRANSPORTER GENE; FUNCTIONAL POLYMORPHISM; ALLELIC ASSOCIATION; BIPOLAR DISORDER; SCHIZOPHRENIA; GENOTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Inada, T Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, 1-7-3 Kohnodai, Ichikawa, Chiba 2720827, Japan Natl Ctr Neurol & Psychiat 1-7-3 Kohnodai Ichikawa Chiba Japan 2720827
Citazione:
A. Nakamura et al., "Association between catechol-O-methyltransferase (COMT) polymorphism and severe alcoholic withdrawal symptoms in male Japanese alcoholics", ADDICT BIOL, 6(3), 2001, pp. 233-238

Abstract

Catechol-O-methyltransferase (COMT) plays a crucial role in central dopaminergic systems. The allelic association of a functional polymorphism of theCOMT gene with the onset, course and clinical characteristics of alcoholism in 91 male Japanese alcoholics and 114 male Japanese controls was examined. There were no statistically significant differences in the frequency of the allele between the alcoholics and the controls. Visual disturbances andauditory disturbances among alcoholic withdrawal symptoms were, however, significantly different among the three groups (p<0.05). The present resultssuggest that COMT activity could partially effect the phenotype of alcoholism, especially the appearance of delirium tremens, in these subjects.

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Documento generato il 07/07/20 alle ore 14:27:19