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Titolo:
The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition
Autore:
Van Noorden, CJF;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands
Titolo Testata:
ACTA HISTOCHEMICA
fascicolo: 3, volume: 103, anno: 2001,
pagine: 241 - 251
SICI:
0065-1281(200107)103:3<241:THOZAT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1-BETA CONVERTING-ENZYME; PEPTIDE-FLUOROMETHYL KETONES; CATHEPSIN-B; CYSTEINE PROTEINASES; CELL-DEATH; IN-VIVO; PROTEASE; ACTIVATION; APOPTOSIS; LIVER;
Keywords:
proteases; proteinases; caspases-apoptosis; histochemistry; cytochemistry; drug discovery; fluorogenic substrates; chromogenic substrates; protease inhibitors;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Van Noorden, CJF Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 15 Amsterdam Netherlands NL-1105 AZ
Citazione:
C.J.F. Van Noorden, "The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition", ACT HISTOCH, 103(3), 2001, pp. 241-251

Abstract

Dr. Robert Smith is one of the pioneers in histochemistry. One of his mostimportant achievements is the recognition of proteolysis as a major physiological and pathophysiological process. As a consequence, he developed selective fluorogenic and chromogenic substrates and specific inhibitors of proteases that allow the (histochemical) analysis of protease activity. One ofthe latest successes is the design of Z-VAD-fluoromethylketone (FMK), the specific caspase inhibitor, that is a key compound for studies on apoptosis. Its development was originally meant for therapeutic use but unforeseen cytotoxicity of a metabolic derivative of the FMK compound disabled its potential as a drug. However, as a tool for fundamental research it is a great success. The history of Z-VAD-FMK is an example of the creative brain and the tireless perseverance of Robert Smith for which histochemistry and cytochemistry owes him so much. This history of Z-VAD-FMK is a well-deserved tribute at the occasion of his 70th birthday.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 08:05:45