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Titolo:
Alterations of left ventricular function in hypertensive pregnant women
Autore:
Schannwell, CM; Schmitz, L; Scheobel, FC; Zimmermann, T; Marx, R; Plehn, G; Leschke, M; Strauer, BE;
Indirizzi:
Univ Dusseldorf, Med Klin & Poliklin B, Klin Kardiol Pneumol & Angiol, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Dusseldorf, Klin Gynakol & Geburtshilfe, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Stadt Kliniken Esslingen, Kardiol Klin, Esslingen, Germany Stadt Kliniken Esslingen Esslingen Germany iol Klin, Esslingen, Germany
Titolo Testata:
ZEITSCHRIFT FUR KARDIOLOGIE
fascicolo: 6, volume: 90, anno: 2001,
pagine: 427 - 436
SICI:
0300-5860(200106)90:6<427:AOLVFI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
GER
Soggetto:
PULMONARY VENOUS FLOW; DOPPLER-ECHOCARDIOGRAPHY; DIASTOLIC FUNCTION; CARDIAC-OUTPUT; MITRAL FLOW; HYPERTROPHY; CARDIOMYOPATHY; ARRHYTHMIAS; VELOCITIES; PRESSURES;
Keywords:
diastolic function; systolic function; pregnancy; mild arterial hypertension; Doppler echocardiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Schannwell, CM Univ Dusseldorf, Med Klin & Poliklin B, Klin Kardiol Pneumol & Angiol, Moorenstr 5, D-40225 Dusseldorf, Germany Univ Dusseldorf Moorenstr 5 Dusseldorf Germany D-40225 any
Citazione:
C.M. Schannwell et al., "Alterations of left ventricular function in hypertensive pregnant women", Z KARDIOL, 90(6), 2001, pp. 427-436

Abstract

Introduction During pregnancy eminent cardiovascular changes occur. The aim of the following study was to investigate the course of hemodynamic parameters under increased volume load during pregnancy in women suffering from mild arterial hypertension. Methods Altogether 47 women (age: 25 +/- 4 years) with mild arterial hypertension detected during pregnancy underwent echocardiography at the 9th, 24th and 33rd week of gestation. Furthermore echocardiography was performed postpartum at weeks 1 and 8. The control group comprised 45 healthy pregnant women. In all patients left ventricular muscle mass index and systolic shortening fraction were measured. The following Doppler echocardiographic parameters were ascertained: peak early diastolic and peak late diastolic flow, V-E/V-A ratio, acceleration time, decelerationtime and isovolumetric relaxation time. Results During pregnancy all patients had an increase of left ventricular muscle mass index and a decrease offractional shortening. All patients developed a relevant diastolic dysfunction. While the control group developed signs of disturbed relaxation as reduction of peak early diastolic flow (0.89 +/- 0.07 versus 0.82 +/- 0.08 m/s*), V-E/V-A ratio and an increase of isovolumetric relaxation time (72 +/-12 versus 123 +/- 7*) at the 33rd week of gestation (* p < 0.01), all pregnant women with mild arterial hypertension developed a diastolic dysfunction with signs of delayed relaxation already at the beginning of gestation. 26 pregnant women with arterial hypertension developed a restrictive diastolic filling pattern at 24 weeks of gestation. The other 21 pregnant women only showed restriction for a short time at the end of gestation. In healthy pregnant women, volume load results in a reversible physiologicleft ventricular hypertrophia, a significant alteration of diastolic left ventricular function in terms of a disturbed relaxation pattern and a temporary decrease of systolic function. In comparison hypertensive pregnant women show a delayed relaxation at the beginning of pregnancy and 50% developed early signs of restrictive cardiomyopathy. These changes may predispose to critical complications during pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 15:36:49