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Titolo:
Cadherins and integrins in renal cell carcinoma an immunohistochemical study
Autore:
Markovic-Lipkovski, J; Brasanac, D; Muller, GA; Muller, CA;
Indirizzi:
Univ Belgrade, Sch Med, Inst Pathol, YU-11000 Belgrade, Yugoslavia Univ Belgrade Belgrade Yugoslavia YU-11000 YU-11000 Belgrade, Yugoslavia Univ Gottingen, Dept Nephrol & Rheumatol, Ctr Internal Med, Gottingen, Germany Univ Gottingen Gottingen Germany , Ctr Internal Med, Gottingen, Germany Univ Tubingen, Med Univ Clin, Sect Transplantat Immunol & Immunohematol, Tubingen, Germany Univ Tubingen Tubingen Germany munol & Immunohematol, Tubingen, Germany
Titolo Testata:
TUMORI
fascicolo: 3, volume: 87, anno: 2001,
pagine: 173 - 178
SICI:
0300-8916(200105/06)87:3<173:CAIIRC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULES; ALPHA-CATENIN; BETA-CATENIN; TUMOR PROGRESSION; N-CADHERIN; EXPRESSION; CANCER; METASTASIS; EPITHELIUM; INVASION;
Keywords:
cadherins; integrins; renal cell carcinoma; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Markovic-Lipkovski, J Univ Belgrade, Sch Med, Inst Pathol, Dr Subotica 1-2, YU-11000 Belgrade, Yugoslavia Univ Belgrade Dr Subotica 1-2 Belgrade Yugoslavia YU-11000
Citazione:
J. Markovic-Lipkovski et al., "Cadherins and integrins in renal cell carcinoma an immunohistochemical study", TUMORI, 87(3), 2001, pp. 173-178

Abstract

Aims and background: The aim of this study was to determine the expressionof cadherins and integrins in renal cell carcinoma (RCC) acid their relationship with tumor morphology and TNM status. Methods: Cadherin and integrin expression was investigated using an indirect immunoperoxidase technique, applying antibodies to E-, N-, P- and VE-cadherin and to alpha (1), alpha (2), alpha (3), alpha (4), alpha (5), alpha (6), and alpha (v) integrin subunits, Correlation of semiquantitatively scored adhesion molecule levels with histopathological parameters (cytology, growth pattern, nuclear grade) and TNM status was performed for 24 RCCs (17 clear cell, 3 granular, 3 spindle cell and 1 chromophobe cell type accordingto the WHO classification). Results: E-cadherin and N-cadherin were present in most cases (88% and 67%, respectively) and were usually coexpressed, T3 RCCs displayed higher E-cadherin and N-cadherin levels than T1/T2 tumors regardless of tumor grade, suggesting that impairment of their function might exist without actual lossfrom tumor cells. P-cadherin was found focally in two RCCs only, while VE-cadherin was present on stromal vessel endothelium in five tumors, showing no differences with regard to cell type, growth pattern, tumor grade or TNMstatus. All integrins were present in the studied RCCs (ranging from 12% for alpha (5) to 79% for alpha (3)), including those that are normally absent from adult kidney tissue (alpha (4) and alpha (5)), Tumors of higher grade showed increased alpha (v) and decreased ors levels, while RCCs with metastases less often showed diffuse ors presence and never expressed alpha (5)integrin. Conclusions: Our results suggest that the level of expression of N-cadherin and some integrins (most notably alpha (3), alpha (6), and alpha (5)) is associated with the capacity of RCC for local and distant spread, regardless of tumor grade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:42:56