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Titolo:
Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models
Autore:
Carlton, JMR; Hayton, M; Cravo, PVL; Walliker, D;
Indirizzi:
NIH, Natl Ctr Biotechnol Res, Natl Lib Med, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 chnol Res, Natl Lib Med, Bethesda, MD 20892 USA Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh EH9 3JT, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH9 3JT Midlothian, Scotland
Titolo Testata:
TRENDS IN PARASITOLOGY
fascicolo: 5, volume: 17, anno: 2001,
pagine: 236 - 242
SICI:
1471-4922(200105)17:5<236:OMAMMU>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM; CHLOROQUINE RESISTANCE; DIHYDROFOLATE-REDUCTASE; CYTOCHROME-B; PYRIMETHAMINE RESISTANCE; DIHYDROPTEROATE SYNTHASE; POINT MUTATIONS; PFMDR1 GENE; IN-VITRO; CHABAUDI;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Carlton, JMR NIH, Natl Ctr Biotechnol Res, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA NIH Bldg 10 Bethesda MD USA 20892 10, Bethesda, MD 20892 USA
Citazione:
J.M.R. Carlton et al., "Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models", TRENDS PARA, 17(5), 2001, pp. 236-242

Abstract

It is well recognized that drug resistance is the most significant obstacle to gaining effective malaria central. Despite the enormous advances in the knowledge of the biochemistry and molecular biology of malaria parasites,only a few genes determining resistance to the commonly used drugs have been identified. The idea that rodent malaria parasites should be exploited more widely for such work, in view of the practical problems of studying this subject experimentally in human malaria, is presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:11:15