Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pre-erythrocytic immunity to Plasmodium falciparum: the case for an LSA-1 vaccine
Autore:
Kurtis, JD; Hollingdale, MR; Luty, AJF; Lanar, DE; Krzych, U; Duffy, PE;
Indirizzi:
Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA Walter Reed Army Inst Res Silver Spring MD USA 20910 Spring, MD 20910 USA Univ London London Sch Hyg & Trop Med, Gates Malaria Programme, London WC1E 7HT, England Univ London London Sch Hyg & Trop Med London England WC1E 7HT T, England Univ Tubingen, Dept Parasitol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 asitol, D-72074 Tubingen, Germany
Titolo Testata:
TRENDS IN PARASITOLOGY
fascicolo: 5, volume: 17, anno: 2001,
pagine: 219 - 223
SICI:
1471-4922(200105)17:5<219:PITPFT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-STAGE ANTIGEN-1; BERGHEI SPOROZOITES; PROTECTIVE IMMUNITY; GAMMA RESPONSES; SEVERE MALARIA; RESISTANCE; CELL; INTERLEUKIN-10; LYMPHOCYTES; IMMUNIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Duffy, PE Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910USA Walter Reed Army Inst Res Silver Spring MD USA 20910 20910 USA
Citazione:
J.D. Kurtis et al., "Pre-erythrocytic immunity to Plasmodium falciparum: the case for an LSA-1 vaccine", TRENDS PARA, 17(5), 2001, pp. 219-223

Abstract

A vaccine is urgently needed to stem the global resurgence of Plasmodium falciparum malaria. Vaccines targeting the erythrocytic stage are often viewed as an anti-disease strategy. By contrast, infection might be completely averted by a vaccine against the liver stage, a pre-erythrocytic stage during which the parasite multiplies 10 000-fold within hepatocytes. Sterilizing immunity can be conferred by inoculating humans with irradiated pre-erythrocytic parasites, and a recombinant pre-erythrocytic vaccine partially protects humans from infection. Liver-stage antigen-1, one of a few proteins known to be expressed by liver-stage parasites, holds particular promise as a vaccine. Studies of naturally exposed populations have consistently related immune responses against this antigen to protection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 14:04:28