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Titolo:
Molecular regulation of lymphangiogenesis and targets for tissue oedema
Autore:
Karkkainen, MJ; Jussila, L; Ferrell, RE; Finegold, DN; Alitalo, K;
Indirizzi:
Univ Helsinki, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ab, FIN-00014 Helsinki, Finland Univ Helsinki, Ludwig Inst Canc Res, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 es, FIN-00014 Helsinki, Finland Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 n Genet, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Pediat, Pittsburgh, PA 15213 USA
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 18 - 22
SICI:
1471-4914(200101)7:1<18:MROLAT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; RECEPTOR TYROSINE KINASES; VEGF-C; LYMPHATIC CAPILLARIES; VASCULAR-PERMEABILITY; OVEREXPRESSING ANGIOPOIETIN-1; LYMPHEDEMA-DISTICHIASIS; HEREDITARY LYMPHEDEMA; TRANSGENIC MICE; BLOOD-VESSELS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Karkkainen, MJ Univ Helsinki, Mol Canc Biol Lab, POB 21 Haartmaninkatu 3, FIN-00014 Helsinki, Finland Univ Helsinki POB 21 Haartmaninkatu 3 HelsinkiFinland FIN-00014
Citazione:
M.J. Karkkainen et al., "Molecular regulation of lymphangiogenesis and targets for tissue oedema", TRENDS MO M, 7(1), 2001, pp. 18-22

Abstract

New insight has recently been obtained into the molecular mechanisms regulating the function of lymphatic endothelial cells. Vascular endothelial growth factors-C and -D have been shown to stimulate lymphangiogenesis. and their receptor VEGFR-3 has been linked to human hereditary lymphoedema. although there is evidence that other genes are also involved. These data suggest that it may become possible to stimulate lymphatic growth and function and to treat tissue oedema involved in many diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 14:46:44