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Titolo:
Genetic clues to the molecular basis of tobacco addiction and progress towards personalized therapy
Autore:
Walton, R; Johnstone, E; Munafo, M; Neville, M; Griffiths, S;
Indirizzi:
Univ Oxford, Dept Primary Hlth Care, Imperial Canc Res Fund, Gen Practice Res Grp,Inst Hlth Sci, Oxford OX3 7LF, England Univ Oxford Oxford EnglandOX3 7LF nst Hlth Sci, Oxford OX3 7LF, England
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 70 - 76
SICI:
1471-4914(200102)7:2<70:GCTTMB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE-RECEPTOR GENE; CIGARETTE-SMOKING; COMPUTER SUPPORT; NICOTINE METABOLISM; OPIATE WITHDRAWAL; CYP2D6; SUBSTRATE; REWARD; BRAIN; DRD2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Walton, R Univ Oxford, Dept Primary Hlth Care, Imperial Canc Res Fund, GenPractice Res Grp,Inst Hlth Sci, Old Rd, Oxford OX3 7LF, England Univ Oxford Old Rd Oxford England OX3 7LF ford OX3 7LF, England
Citazione:
R. Walton et al., "Genetic clues to the molecular basis of tobacco addiction and progress towards personalized therapy", TRENDS MO M, 7(2), 2001, pp. 70-76

Abstract

The molecular processes that underlie addiction are beginning to unfold. Genetically determined variations in dopaminergic neurotransmission predispose to nicotine dependence In addition, tobacco use is likely to be governedby the rate at which smokers metabolize nicotine. Functional polymorphismsin cytochrome P450 monooxygenases that metabolize nicotine have now been defined and it should soon be possible to identify fast nicotine metabolizers by DNA analysis. Here, we review the key neurotransmitter receptors and metabolic enzymes implicated in tobacco dependence. We explore the potentialbenefits of classifying smokers according to the molecular aetiology of their habit. One major benefit will be in planning effective strategies for smoking cessation. Methods of typing for alleles related to smoking behaviorthat might be suitable for use in clinical practice in the future will also be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:04:11