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Titolo:
Biological effects of growth hormone and its antagonist
Autore:
Okada, S; Kopchick, JJ;
Indirizzi:
Ohio Univ, Coll Osteopath Med, Edison Biotechnol Inst, Mol & Cellular BiolProgram, Athens, OH 45701 USA Ohio Univ Athens OH USA 45701 Cellular BiolProgram, Athens, OH 45701 USA Ohio Univ, Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA Ohio Univ Athens OH USA 45701 Med, Dept Biomed Sci, Athens, OH 45701 USA
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 3, volume: 7, anno: 2001,
pagine: 126 - 132
SICI:
1471-4914(200103)7:3<126:BEOGHA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-RECEPTOR SUBSTRATE-1; FACTOR-I; TRANSGENIC MICE; GH RECEPTOR; TYROSINE PHOSPHORYLATION; SCANNING MUTAGENESIS; EXTRACELLULAR DOMAIN; PROMOTING ACTIVITY; PROSTATE-CANCER; BINDING-PROTEIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Kopchick, JJ Ohio Univ, Coll Osteopath Med, Edison Biotechnol Inst, Mol & Cellular BiolProgram, Athens, OH 45701 USA Ohio Univ Athens OH USA 45701 lProgram, Athens, OH 45701 USA
Citazione:
S. Okada e J.J. Kopchick, "Biological effects of growth hormone and its antagonist", TRENDS MO M, 7(3), 2001, pp. 126-132

Abstract

Serum levels of growth hormone (GH) can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and has been implicated in diabetic eye and kidney damage. Additionally the GH/IGF-1 system has been postulated as a risk factor for several types of cancers. Thus both elevated and suppressed circulating levels of GH can have pronounced physiological effects. More than a decade ago the first drug of a new class, a GH antagonist, was discovered. Thismolecule is now being tested for its ability to combat the effects of highcirculating levels of GH, Here, we discuss some of the detrimental actionsof GH, and how a GH antagonist can be used to combat these effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:41:35