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Titolo:
Molecular basis of partial lipodystrophy and prospects for therapy
Autore:
Hegele, RA;
Indirizzi:
Robarts Res Inst, Blackburn Cardiovasc Genet Lab, London, ON N6A 5K8, Canada Robarts Res Inst London ON Canada N6A 5K8 Lab, London, ON N6A 5K8, Canada
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 3, volume: 7, anno: 2001,
pagine: 121 - 126
SICI:
1471-4914(200103)7:3<121:MBOPLA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL PARTIAL LIPODYSTROPHY; DREIFUSS MUSCULAR-DYSTROPHY; ACTIVATED RECEPTOR-ALPHA; ENCODING LAMIN A/C; INSULIN-RESISTANCE; DUNNIGAN VARIETY; R482Q MUTATION; CHROMOSOME 1Q21-22; MISSENSE MUTATIONS; GENE-EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Hegele, RA Robarts Res Inst, Blackburn Cardiovasc Genet Lab, 406-100 Perth, London, ON N6A 5K8, Canada Robarts Res Inst 406-100 Perth London ON Canada N6A 5K8 Canada
Citazione:
R.A. Hegele, "Molecular basis of partial lipodystrophy and prospects for therapy", TRENDS MO M, 7(3), 2001, pp. 121-126

Abstract

Lipodystrophy is characterized by altered partition of adipose tissue. Despite heterogeneous causes, which include genetic, autoimmune and drug-induced forms, lipodystrophy syndromes have similar metabolic attributes, including insulin resistance, hyperlipidemia and diabetes. The mechanisms underlying the insulin resistance are unknown. One form of lipodystrophy. namely Dunnigan-type familial partial lipodystrophy (FPLD) was shown to result frommutations in the LMVA gene, which encodes nuclear lamins A and C. Althoughthe relationship between the mutations in the nuclear envelope and insulinresistance is unclear at present these findings might eventually be shown to have relevance for the common insulin resistance syndrome and for drug-associated lipodystrophies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 19:01:01