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Titolo:
Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy
Autore:
Lassmann, H; Bruck, W; Lucchinetti, C;
Indirizzi:
Univ Vienna, Inst Brain Res, Div Neuroimmunol, A-1090 Vienna, Austria UnivVienna Vienna Austria A-1090 v Neuroimmunol, A-1090 Vienna, Austria Inst Neuropathol, Charite, D-13353 Berlin, Germany Inst Neuropathol Berlin Germany D-13353 Charite, D-13353 Berlin, Germany Mayo Clin, Dept Neurol, Rochester, MN 55905 USA Mayo Clin Rochester MN USA 55905 in, Dept Neurol, Rochester, MN 55905 USA
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 3, volume: 7, anno: 2001,
pagine: 115 - 121
SICI:
1471-4914(200103)7:3<115:HOMSPI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; T-CELL RESPONSES; BASIC-PROTEIN; AUTOIMMUNE ENCEPHALOMYELITIS; LESIONS; DISEASE; DEMYELINATION; DEGENERATION; CNS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lassmann, H Univ Vienna, Inst Brain Res, Div Neuroimmunol, Spitalgasse 4, A-1090 Vienna, Austria Univ Vienna Spitalgasse 4 Vienna Austria A-1090 enna, Austria
Citazione:
H. Lassmann et al., "Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy", TRENDS MO M, 7(3), 2001, pp. 115-121

Abstract

Multiple sclerosis is a chronic inflammatory disease of the nervous systemin which a T-cell-mediated inflammatory process is associated with destruction of myelin sheaths. Although demyelination is the primary event, axons are also destroyed in the lesions, and the loss of axons correlates with permanent functional deficit. Here, we discuss evidence that demyelination and axonal destruction follow different pathogenetic pathways in subgroups ofpatients. This might, at least in part, explain the heterogeneity in genetic susceptibility, clinical presentation and response to treatment observedbetween individuals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:56:38