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Titolo:
Searching for schizophrenia genes
Autore:
Bray, NJ; Owen, MJ;
Indirizzi:
Univ Coll N Wales, Coll Med, Dept Med Psychol, Neuropsychiat Genet Unit, Cardiff CF4 4XN, S Glam, Wales Univ Coll N Wales Cardiff S Glam Wales CF4 4XN iff CF4 4XN, S Glam, Wales
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 169 - 174
SICI:
1471-4914(200104)7:4<169:SFSG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CARDIO-FACIAL SYNDROME; D2 DOPAMINE-RECEPTORS; SUSCEPTIBILITY LOCUS; LINKAGE ANALYSIS; ASSOCIATION; FAMILIES; BRAIN; NEUROPATHOLOGY; TRANSLOCATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Owen, MJ Univ Coll N Wales, Coll Med, Dept Med Psychol, Neuropsychiat Genet Unit, Cardiff CF4 4XN, S Glam, Wales Univ Coll N Wales Cardiff S Glam Wales CF4 4XN XN, S Glam, Wales
Citazione:
N.J. Bray e M.J. Owen, "Searching for schizophrenia genes", TRENDS MO M, 7(4), 2001, pp. 169-174

Abstract

Schizophrenia is characterized by profound disturbances of cognition, emotion and social functioning. It carries a lifetime risk within the general population of approximately 1 %. Genetic epidemiological studies have shown th at the syndrome has a high heritability, indicating a significant genetic component to its aetiology. However, the undoubted complexity and probable heterogeneity of the disorder continue to confound research, and the precise underlying neurobiological mechanisms remain largely unknown. Although moleculargenetic approaches face formidable difficulties, the identification of susceptibility genes is likely to provide valuable insights into the aetiology and pathogenesis that could lead to the development of more effective treatments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:32:11