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Titolo:
Oocyte activation: lessons from human infertility
Autore:
Ben-Yosef, D; Shalgi, R;
Indirizzi:
LIS Matern Hosp, Racine IVF Unit, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel LIS Matern Hosp Tel Aviv Israel IL-64239 Ctr, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Dept Embryol & Teratol, IL-69978 Tel Aviv,Israel Tel Aviv Univ Tel Aviv Israel IL-69978 Teratol, IL-69978 Tel Aviv,Israel
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 163 - 169
SICI:
1471-4914(200104)7:4<163:OALFHI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACYTOPLASMIC SPERM INJECTION; MAMMALIAN EGG ACTIVATION; MOUSE EGGS; IMMOTILE SPERMATOZOA; INTRACELLULAR PH; CYTOSOLIC FACTOR; CELL-CYCLE; CALCIUM OSCILLATIONS; CORTICAL GRANULES; CA2+ OSCILLATIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Shalgi, R LIS Matern Hosp, Racine IVF Unit, Tel Aviv Sourasky Med Ctr, IL-64239 Tel Aviv, Israel LIS Matern Hosp Tel Aviv Israel IL-64239 4239 Tel Aviv, Israel
Citazione:
D. Ben-Yosef e R. Shalgi, "Oocyte activation: lessons from human infertility", TRENDS MO M, 7(4), 2001, pp. 163-169

Abstract

During fertilization, the spermatozoon penetrates through the cumulus cells and the zona pellucida that surrounds the oocyte, before it binds and fuses with the oocyte plasma membrane to induce activation. In vitro fertilization (IVF) studies performed in non-human mammals have contributed extensive knowledge regarding the mechanisms by which the spermatozoon activates the meiotic-arrested oocyte to resume meiosis, cleave and develop into an embryo. Although IVF has been used extensively for treating subfertile couples, not all of them were able to benefit from this procedure. In intracytoplasmic sperm injection (ICSI), one viable spermatozoononly is sufficient for successful fertilization of a single oocyte, Moreover, the injected fertilizing spermatozoon bypasses several physiological barriers, compared with IVF, which together could explain the high success rate for this procedure. ICSI has also allowed the identification of sperm components that are required for successful fertilization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:35:53