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Titolo:
Presenilins as therapeutic targets for the treatment of Alzheimer's disease
Autore:
Golde, TE; Younkin, SG;
Indirizzi:
Mayo Clin Jacksonville, Dept Neurosci, Jacksonville, FL 32224 USA Mayo Clin Jacksonville Jacksonville FL USA 32224 cksonville, FL 32224 USA
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 6, volume: 7, anno: 2001,
pagine: 264 - 269
SICI:
1471-4914(200106)7:6<264:PATTFT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; GAMMA-SECRETASE ACTIVITY; CAPACITATIVE CALCIUM-ENTRY; BETA-SECRETASE; INTRACELLULAR DOMAIN; SIGNAL-TRANSDUCTION; IN-VIVO; NOTCH; ENDOPROTEOLYSIS; INHIBITORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Golde, TE Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL32224 USA Mayo Clin Jacksonville 4500 San Pablo Rd Jacksonville FL USA 32224
Citazione:
T.E. Golde e S.G. Younkin, "Presenilins as therapeutic targets for the treatment of Alzheimer's disease", TRENDS MO M, 7(6), 2001, pp. 264-269

Abstract

Studies demonstrating that accumulation and aggregation of the amyloid beta protein (A beta) within the brain is likely to cause Alzheimer's disease (AD) have provided the rationale for therapeutic strategies aimed at influencing A beta production, aggregation and clearance. gamma -secretase catalyzes the final cleavage that releases the A beta from its precursor; therefore, it is a potential therapeutic target for the treatment of AD. Recent data show that the polytopic membrane proteins presenilin 1 and presenilin 2 are either catalytic components or essential co-factors of a membrane-boundproteolytic complex that possesses gamma -secretase activity, Although recent findings demonstrating that gamma -secretase inhibitors bind directly to presenilins (PSs) further support a catalytic role for PSs in gamma -secretase cleavage, additional studies ate still needed to clarify the role of PSs in gamma -secretase cleavage and the use of targeting PSs to reduce A beta production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:35:13