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Titolo:
Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries
Autore:
Schwartz, M; Kipnis, J;
Indirizzi:
Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 biol, IL-76100 Rehovot, Israel
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 6, volume: 7, anno: 2001,
pagine: 252 - 258
SICI:
1471-4914(200106)7:6<252:PARAPF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; CENTRAL-NERVOUS-SYSTEM; POTENTIAL NEUROPROTECTIVE THERAPY; ALTERED PEPTIDE LIGAND; RETINAL GANGLION-CELLS; T-CELLS; MULTIPLE-SCLEROSIS; OPTIC-NERVE; DEMYELINATING DISEASE; NEUROTROPHIC FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartz, M Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 00 Rehovot, Israel
Citazione:
M. Schwartz e J. Kipnis, "Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries", TRENDS MO M, 7(6), 2001, pp. 252-258

Abstract

Neuronal degeneration after traumatic injury to the central nervous system(CNS) can be reduced by active immunization or passive transfer of T cellsagainst CNS-associated myelin antigens, We propose that a protective autoimmunity is evoked by CNS insult when non-immunological local protective mechanisms cannot adequately buffer the injury-induced toxicity. The ability of a particular strain to develop a protective autoimmune response appears to be inversely related to its susceptibility to autoimmune disease. We alsopropose that vaccination with specific CNS-derived 'safe' (non-pathogenic)peptides after traumatic CNS insult, and possibly at any stage of chronic neurodegenerative disease, can be used to boost the protective autoimmunityacid thereby to reduce further injury-induced damage. Such therapeutic vaccination ensures that the augmented beneficial autoimmunity will be free ofaccompanying disease.

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Documento generato il 22/01/20 alle ore 09:18:22