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Titolo:
Mechanism of anti-D-mediated immune suppression - a paradox awaiting resolution?
Autore:
Kumpel, BM; Elson, CJ;
Indirizzi:
Bristol Inst Transfus Sci, Int Blood Grp Reference Lab, Bristol BS10 5ND, Avon, England Bristol Inst Transfus Sci Bristol Avon England BS10 5ND ND, Avon, England Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Bristol BS8 1TD, Avon,England Univ Bristol Bristol Avon England BS8 1TD , Bristol BS8 1TD, Avon,England
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 1, volume: 22, anno: 2001,
pagine: 26 - 31
SICI:
1471-4906(200101)22:1<26:MOAIS->2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITIVE RED-CELLS; HEMOLYTIC-DISEASE; DEFICIENT MICE; RH PROPHYLAXIS; IGG; IMMUNOGLOBULIN; RECEPTOR; BINDING; RESPONSES; CLEARANCE;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Kumpel, BM Bristol Inst Transfus Sci, Int Blood Grp Reference Lab, BristolBS10 5ND, Avon, England Bristol Inst Transfus Sci Bristol Avon England BS10 5ND ngland
Citazione:
B.M. Kumpel e C.J. Elson, "Mechanism of anti-D-mediated immune suppression - a paradox awaiting resolution?", TRENDS IMMU, 22(1), 2001, pp. 26-31

Abstract

During pregnancy, women can be immunized by fetal red blood cells (RBCs) of an incompatible blood group. Subsequent transplacental passage of the antibodies can result in fetal morbidity or mortality due to RBC destruction. The administration of anti-D antibodies to D- women after delivery of a D+ infant, and subsequent prevention of Rhesus (Rh) D haemolytic disease of the fetus and newborn, is the most successful clinical use of antibody-mediated im mu ne suppression. The passive IgG anti-D might prevent immunization to D+ RBCs by an IgG Fc gamma receptor (Fc gammaR)-dependent mechanism suchas crosslinking the D-specific B-cell receptor and inhibitory Fc gamma RIIb, However, recent murine studies demonstrate that the suppressive effects of antibodies to heterologous RBCs can be Fc gammaR-independent. suggestingother mechanisms might contribute.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 15:45:23