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Titolo:
Complex layers of genetic alteration in the generation of antibody diversity
Autore:
Muramatsu, M; Honjo, T;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Med Chem, Sakyo Ku, Kyoto 6068501, Japan
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 66 - 68
SICI:
1471-4906(200102)22:2<66:CLOGAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTIDINE DEAMINASE AID; HYPER-IGM SYNDROME; SOMATIC HYPERMUTATION; IMMUNOGLOBULIN GENES; CLASS SWITCH; B-CELLS; RNA; DELETIONS;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Muramatsu, M Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Konoe Cho,Kyoto 6068501, Japan Kyoto Univ Konoe Cho Kyoto Japan 6068501 yoto 6068501, Japan
Citazione:
M. Muramatsu e T. Honjo, "Complex layers of genetic alteration in the generation of antibody diversity", TRENDS IMMU, 22(2), 2001, pp. 66-68

Abstract

The diversity of the immune system is known to be somatically amplified byvarious genetic alteration mechanisms including V(D)J recombination, somatic hypermutation (SH) and class switch recombination (CSR). Recent findingsthat both CSR and SH are abolished by mutations of mouse and human AID, a member of the RNA-editing cytidine deaminase family, suggest that at least dual layers of genetic alteration mechanisms are involved in the generationof immune diversity.

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Documento generato il 29/03/20 alle ore 15:16:38