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Titolo:
TB vaccines: progress and problems
Autore:
Andersen, P;
Indirizzi:
Statens Serum Inst, Dept TB Immunol, DK-2300 Copenhagen, Denmark Statens Serum Inst Copenhagen Denmark DK-2300 K-2300 Copenhagen, Denmark
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 3, volume: 22, anno: 2001,
pagine: 160 - 168
SICI:
1471-4906(200103)22:3<160:TVPAP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIUM-TUBERCULOSIS INFECTION; BACILLUS-CALMETTE-GUERIN; GUINEA-PIG MODEL; PROTECTIVE EFFICACY; DNA VACCINES; ANTIMYCOBACTERIAL IMMUNITY; TRANSPOSON MUTAGENESIS; EXTRACELLULAR PROTEINS; IMMUNOLOGICAL MEMORY; AEROSOL INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Andersen, P Statens Serum Inst, Dept TB Immunol, 5 Artillerivej, DK-2300 Copenhagen, Denmark Statens Serum Inst 5 Artillerivej Copenhagen Denmark DK-2300
Citazione:
P. Andersen, "TB vaccines: progress and problems", TRENDS IMMU, 22(3), 2001, pp. 160-168

Abstract

Tuberculosis (TB) is the biggest killer worldwide of any infectious disease, a situation worsened by the advent of the HIV epidemic and the emergenceof multi-drug resistant strains of Mycobacterium tuberculosis. The existing vaccine, Mycobacterium bovis bacille Calmette-Guerin (BCG). has proven inefficient in several recent field trials. There is currently intense research using cutting-edge vaccine technology to combat this ancient disease, However, it is necessary to understand why BCG has failed before we can rationally develop the next generation of vaccines. Several hypotheses that might explain the failure of BCG and the strategies designed to address these shortcomings are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:05:45