Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The expanding world of co-stimulation: the two-signal model revisited
Autore:
Chambers, CA;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 Pathol, Worcester, MA 01655 USA
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 4, volume: 22, anno: 2001,
pagine: 217 - 223
SICI:
1471-4906(200104)22:4<217:TEWOCT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; DEVELOPMENTALLY-REGULATED EXPRESSION; LYMPHOCYTE-ASSOCIATED ANTIGEN-4; HUMAN PD-1 GENE; COSTIMULATORY MOLECULE; B7 FAMILY; PD-1-DEFICIENT MICE; PROTEIN ICOS; CD80 B7-1; CTLA-4;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Chambers, CA Univ Massachusetts, Sch Med, Dept Pathol, 55 Lake Ave N, Worcester, MA 01655 USA Univ Massachusetts 55 Lake Ave N Worcester MA USA 016555 USA
Citazione:
C.A. Chambers, "The expanding world of co-stimulation: the two-signal model revisited", TRENDS IMMU, 22(4), 2001, pp. 217-223

Abstract

The crucial role for CD28. its homolog CTLA-4 and their binding partners B7-1 and B7-2 in the generation of effective T-cell responses has been well documented. Recently, two new pairs of the CD28/B7 families were identified. The ability of these molecules to regulate T-cell expansion and effector function and the dynamic integration of the co-stimulatory and T-cell receptor signals are just beginning to be explored. Understanding these processes will be crucial for designing clinically relevant approaches to manipulate the adaptive immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:55:57