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Titolo:
VAP-1: an adhesin and an enzyme
Autore:
Salmi, M; Jalkanen, S;
Indirizzi:
Univ Turku, MediCity Res Lab, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ity Res Lab, FIN-20520 Turku, Finland
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 4, volume: 22, anno: 2001,
pagine: 211 - 216
SICI:
1471-4906(200104)22:4<211:VAAAAE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE AMINE OXIDASE; PROTEIN-1 VAP-1; LYMPHOCYTE BINDING; VASCULAR ENDOTHELIUM; MONOAMINE-OXIDASE; CELL-SURFACE; MOLECULE; COPPER; INFLAMMATION; RECOGNITION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Salmi, M Univ Turku, MediCity Res Lab, Tykistokatu 6A, FIN-20520 Turku, Finland Univ Turku Tykistokatu 6A Turku Finland FIN-20520 Turku, Finland
Citazione:
M. Salmi e S. Jalkanen, "VAP-1: an adhesin and an enzyme", TRENDS IMMU, 22(4), 2001, pp. 211-216

Abstract

Leukocyte extravasation from the blood into tissues is of paramount importance for normal immunosurveillance and in mounting adequate inflammatory responses. Multiple traditional adhesion molecules and chemoattractants on leukocytes and endothelial cells are involved in the emigration process. Vascular adhesion protein 1 (VAP-1) is a nonclassical inflammation-inducible endothelial molecule involved in leukocyte-subtype-specific rolling under physiological shear. Molecularly. VAP-1 belongs to a special class of cell surface amino oxidases, The enzymatic reaction itself and the biologically active end products can potentially regulate the adhesive status of the vesselwall. Thus, VAP-1 is an ectoenzyme that has inter-related adhesive and enzymatic functions in regulating physiological trafficking and inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:50:32