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Titolo:
Interaction of T cells with APCs: the serial encounter model
Autore:
Friedl, P; Gunzer, M;
Indirizzi:
Univ Wurzburg, Dept Dermatol, Cell Migrat Lab, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 at Lab, D-97080 Wurzburg, Germany Univ Munster, Dept Dermatol, D-84149 Munster, Germany Univ Munster Munster Germany D-84149 Dermatol, D-84149 Munster, Germany
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 4, volume: 22, anno: 2001,
pagine: 187 - 191
SICI:
1471-4906(200104)22:4<187:IOTCWA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENDRITIC CELLS; ACTIN CYTOSKELETON; B-CELLS; INTRACELLULAR CALCIUM; IMMUNOLOGICAL SYNAPSE; EXTRACELLULAR-MATRIX; ANTIGEN PRESENTATION; COLLAGEN LATTICES; LYMPH-NODE; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Friedl, P Univ Wurzburg, Dept Dermatol, Cell Migrat Lab, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 ny
Citazione:
P. Friedl e M. Gunzer, "Interaction of T cells with APCs: the serial encounter model", TRENDS IMMU, 22(4), 2001, pp. 187-191

Abstract

Primary immune responses are initiated by specific physical interaction ofantigen-specific T cells and professional antigen-presenting cells (APCs). Productive interactions can be a dynamic process that combines physical T-cell binding to APCs with vigorous crawling across and scanning of the APC surface, resulting in signal induction. After T-cell detachment, subsequentmigratory contacts to the same or neighboring dendritic cells (DCs) allow the accumulation of sequential signals and interaction time. Here, we develop a serial encounter model of T-cell activation and discuss how the summation of multiple signals provides an efficient strategy to control an ongoing immune response.

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Documento generato il 04/04/20 alle ore 08:31:11